Table 1 HFI prevalence estimation in Child Cohort and Parent Cohort with estimated affected frequency by three methods
From: Estimation of hereditary fructose intolerance prevalence in the Chinese population
| Â | CCGT child cohort | CCGT parent cohort |
|---|---|---|
Total number | 20,919 | 10,031 |
Gender (male/female) | 12,783/8136 | 5006/5024 |
Carrier with P/LP variants (male/female) | 61 (36/25) | 27(11/16) |
Carrier frequency | 1/342 | 1/371 |
Couple’s carrier risk | 1/117604 | 1/138026 |
Method 1: carrier frequency | 1/470416 | 1/552104 |
Method2: permutation and combination | 1/462233 | 1/571594 |
Method 3: Bayesian framework (95% CI) | 1/462839 (1/803692 ~ 1/293567) | 1/532412 (1/1270634 ~ 1/277464) |
Average | 1/465133 | 1/551573 |
Estimated HFI frequency | 1/504678 | |