Skip to main content

Table 6 The comparison of disease milestones and clinical presentations between Gly83Arg and non-Gly83Arg

From: Clinical phenotypes and genetic features of hereditary transthyretin amyloidosis patients in China

Feature Gly83Arg (p.Gly103Arg) Other genotypes P value
N 25 101  
% Male 52.00% 73.27% 0.07
% Family history 100.00% 78.22% < 0.01
Age at presentation onset, years, mean (SD) 39.36 (4.06) 42.39 (13.01) 0.69
Age at diagnosis, years, mean (SD) 47.76 (7.88) 46.81 (15.12) 0.49
Age at death, years, mean (SD) 47.19 (10.23)
Time from presentation onset to diagnosis, years, mean (SD) 8.50 (5.30) 5.32 (5.90) < 0.01
Time from presentation onset to death, years, median (IQR) 7.50 (5.30)
Autonomic 0 (0.00%) 73 (72.28%) < 0.01
Sensory/motor 10 (40.00%) 81 (80.20%) < 0.01
Cardiologic 1 (4.00%) 38 (37.62%) < 0.01
Visual 25 (100.00%) 38 (37.62%) < 0.01
Other 0 (0.00%) 18 (17.82%) 0.02