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Table 3 Participants’ expectation on undergoing genetic screening

From: Current attitudes and preconceptions on newborn genetic screening in the Chinese reproductive-aged population

  Is it necessary to undergo genetic screening? Value P
Total (n = 1141, 100%) Yes (n = 989, 86.68%) No/I don’t know (n = 152, 13.32%)
Do you think it is necessary to increase the number of diseases in NBS?
 Yes 930 (81.51%) 861 (87.06%) 69 (45.39%)   
 No 15 (1.31%) 11 (1.11%) 4 (2.63%) 154.865 P < 0.05
 Have no idea 34 (2.98%) 22 (2.22%) 12 (7.90%)   
 Consult doctor 162 (14.20%) 95 (9.61%) 67 (44.08%)   
How many new diseases do you wish to be added to NBS?
 As many and comprehensive as possible 821 (71.96%) 734 (74.22%) 87 (57.24%) 88.685 P < 0.05
 Add another 10–50 types with a relatively high incidence 257 (22.52%) 225 (22.75%) 32 (21.05%)   
 No need to add any new diseases 63 (5.52%) 30 (3.03%) 33 (21.71%)   
The cost of NBS may increase with the number of screening diseases. How much are you willing to pay for the NBS after expanding the types of diseases?
  < 1000 RMB 181 (15.86%) 135 (13.65%) 46 (30.26%)   
 1000–2000 RMB 678 (59.42%) 594 (60.06%) 84 (55.26%) 30.875 P < 0.05
  > 2000 RMB 282 (24.72%) 260 (26.29%) 22 (14.48%)   
What is the minimum detection rate for each disease in newborn genetic screening that you can accept?
  > 95% 625 (54.78%) 554 (56.02%) 71 (46.71%)   
  > 75% 163 (14.28%) 148 (14.96%) 15 (9.87%)   
  > 60% 102 (8.94%%) 87 (8.80%) 15 (9.87%) 15.290 P < 0.05
  > 30% 251 (22.00%) 200 (20.22%) 51 (33.55%)   
For low onset genetic diseases, the detection rate of genetic screening is low. What is the minimum detection rate for these diseases in newborn genetic screening that you can accept?
  > 80% 586 (51.36%) 519 (52.48%) 67 (44.08%)   
  > 65% 194 (17.00%) 164 (16.58%) 30 (19.74%) 8.576 P < 0.05
  > 50% 123 (10.78%) 111 (11.22%) 12 (7.89%)   
  > 30% 238 (20.86%) 195 (19.72%) 43 (28.29%)