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Table 3 Concomitant antidepressants, antihypertensives, antiemetics, and analgesics at baseline

From: Disease burden in patients with acute hepatic porphyria: experience from the phase 3 ENVISION study

 

Placebo (n = 46)

Givosiran (n = 48)

Total (N = 94)

Antidepressants

 Benzodiazepine derivatives

10 (22)

10 (21)

20 (21)

 Benzodiazepine-related drugs

3 (7)

4 (8)

7 (7)

 Other anti-depressants

4 (9)

9 (19)

13 (14)

 SSRIs

2 (4)

4 (8)

6 (6)

Antihypertensives

 ACE inhibitors

2 (4)

1 (2)

3 (3)

 Angiotensin II receptor antagonists

3 (7)

2 (4)

5 (5)

 Beta blocking agents, non-selective

1 (2)

3 (6)

4 (4)

 Beta blocking agents, selective

5 (11)

7 (15)

12 (13)

Antiemetics

 5HT3 antagonists

12 (26)

12 (25)

24 (26)

Pain medications

 Natural opium alkaloids

27 (59)

23 (48)

50 (53)

 Opioid anesthetics (fentanyl)

2 (4)

0

2 (2)

 Opioid/non-opioid combinations

2 (4)

5 (10)

7 (7)

 Opium alkaloid derivatives

2 (4)

0

2 (2)

 Other opioids

8 (17)

6 (13)

14 (15)

 Other analgesics and antipyretics

10 (22)

13 (27)

23 (25)

  1. SSRI selective serotonin reuptake inhibitor, ACE angiotensin-converting enzyme, 5HT3 5-hydroxytryptamine