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Table 3 Clinician global assessment of wound surface area as percentage of body surface area by in-person direct visualization and remote (photographic) assessment of 2-dimensional digital images

From: A prospective short-term study to evaluate methodologies for the assessment of disease extent, impact, and wound evolution in patients with dystrophic epidermolysis bullosa

  CGA of WSA (% of BSA)
Mild
N = 9
Moderate
N = 10
Severe
N = 11
Overall
N = 30
Direct Remote Difference Direct Remote Difference Direct Remote Difference Direct Remote Difference
Baseline n = 9 n = 10 n = 11 n = 30
 Mean (SD) 2.8 (2.0) 2.5 (2.2) 0.3 (0.6) 8.4 (7.7) 6.4 (6.4) 2.0 (3.9) 13.1 (9.0) 9.3 (6.3) 3.8 (4.3) 8.4 (8.1) 6.3 (5.9) 2.1 (3.7)
 Median (range) 2.1 (0.2–‍6.0) 2.2 (0.1–‍6.5) 0.1 (− 0.5 to ‍1.3) 5.1 (0.4–‍20.7) 4.6 (0.4–‍20.5) 1.0 (− 0.2 to ‍13.0) 9.3 (3.8–‍32.0) 6.1 (4.1–‍23.7) 2.1 (− 0.3 to ‍12.1) 6.1 (0.2–‍32.0) 4.8 (0.1–‍23.7) 0.8 (− 0.5 to ‍13.0)
Week 2 n = 9 n = 9 n = 11 n = 29
 Mean (SD) 2.2 (1.5) 1.9 (1.6) 0.3 (0.5) 9.1 (8.9) 6.5 (5.7) 2.9 (7.3) 13.0 (9.4) 10.1 (7.2) 2.9 (4.8) 8.4 (8.7) 6.3 (6.3) 2.1 (5.0)
 Median (range) 1.6 (0.1–‍4.8) 1.4 (0.2–‍4.8) 0.2 (− 0.4 to ‍1.1) 6.8 (1.0–‍27.2) 5.2 (0.8–‍19.0) 0.2 (− 0.8 to ‍22.0) 9.5 (5.4–‍31.3) 8.2 (3.4–‍27.6) 1.3 (− 1.8 to ‍14.7) 5.8 (0.1–‍31.3) 4.8 (0.2–‍27.6) 0.5 (− 1.8 to ‍22.0)
Week 4 n = 9 n = 9 n = 11 n = 29
 Mean (SD) 2.1 (1.7) 1.9 (2.0) 0.1 (0.6) 9.3 (10.1) 7.2 (8.4) 2.1 (7.4) 12.8 (10.2) 9.3 (7.8) 3.5 (4.4) 8.4 (9.4) 6.4 (7.3) 2.0 (4.9)
 Median (range) 1.7 (0.2–‍5.4) 1.4 (0.1–‍5.7) 0.1 (− 0.7 to ‍1.4) 5.8 (0.7–‍26.7) 3.9 (0.5–‍26.4) 0.3 (− 3.7 to ‍21.0) 8.8 (4.9–‍33.4) 5.5 (2.3–‍29.0) 3.0 (− 0.6 to ‍15.2) 5.2 (0.2–‍33.4) 4.5 (0.1–‍29.0) 0.3 (− 3.7 to ‍21.0)
Change from baseline at week 4 n = 9 n = 9 n = 11 n = 29
 Mean (SD) − 0.7 (1.1) − 0.6 (1.1) NA 0.3 (3.8) 0.3 (3.0) NA − 0.3 (5.5) 1.0 (4.0) NA − 0.2 (4.0) − 0.1 (2.9) NA
 Median (range) − 0.5 (− 3.0 to ‍0.5) − 0.5 (− 2.3 to ‍0.8)   1.1 (− 5.8 to ‍6.0) 0.1 (− 3.5 to ‍5.9)   − 0.5 (− 9.9 to ‍7.6) 0.1 (− 8.9 to ‍5.4)   0.0 (− 9.9 to ‍7.6) 0.0 (− 8.9 to ‍5.9)  
  1. CGAs for each method were calculated using the rule of nines
  2. BSA body surface area, CGA clinician global assessment, NA not applicable, WSA wound surface area