CGA of WSA (% of BSA) | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Mild N = 9 | Moderate N = 10 | Severe N = 11 | Overall N = 30 | |||||||||
Direct | Remote | Difference | Direct | Remote | Difference | Direct | Remote | Difference | Direct | Remote | Difference | |
Baseline | n = 9 | n = 10 | n = 11 | n = 30 | ||||||||
Mean (SD) | 2.8 (2.0) | 2.5 (2.2) | 0.3 (0.6) | 8.4 (7.7) | 6.4 (6.4) | 2.0 (3.9) | 13.1 (9.0) | 9.3 (6.3) | 3.8 (4.3) | 8.4 (8.1) | 6.3 (5.9) | 2.1 (3.7) |
Median (range) | 2.1 (0.2–6.0) | 2.2 (0.1–6.5) | 0.1 (− 0.5 to 1.3) | 5.1 (0.4–20.7) | 4.6 (0.4–20.5) | 1.0 (− 0.2 to 13.0) | 9.3 (3.8–32.0) | 6.1 (4.1–23.7) | 2.1 (− 0.3 to 12.1) | 6.1 (0.2–32.0) | 4.8 (0.1–23.7) | 0.8 (− 0.5 to 13.0) |
Week 2 | n = 9 | n = 9 | n = 11 | n = 29 | ||||||||
Mean (SD) | 2.2 (1.5) | 1.9 (1.6) | 0.3 (0.5) | 9.1 (8.9) | 6.5 (5.7) | 2.9 (7.3) | 13.0 (9.4) | 10.1 (7.2) | 2.9 (4.8) | 8.4 (8.7) | 6.3 (6.3) | 2.1 (5.0) |
Median (range) | 1.6 (0.1–4.8) | 1.4 (0.2–4.8) | 0.2 (− 0.4 to 1.1) | 6.8 (1.0–27.2) | 5.2 (0.8–19.0) | 0.2 (− 0.8 to 22.0) | 9.5 (5.4–31.3) | 8.2 (3.4–27.6) | 1.3 (− 1.8 to 14.7) | 5.8 (0.1–31.3) | 4.8 (0.2–27.6) | 0.5 (− 1.8 to 22.0) |
Week 4 | n = 9 | n = 9 | n = 11 | n = 29 | ||||||||
Mean (SD) | 2.1 (1.7) | 1.9 (2.0) | 0.1 (0.6) | 9.3 (10.1) | 7.2 (8.4) | 2.1 (7.4) | 12.8 (10.2) | 9.3 (7.8) | 3.5 (4.4) | 8.4 (9.4) | 6.4 (7.3) | 2.0 (4.9) |
Median (range) | 1.7 (0.2–5.4) | 1.4 (0.1–5.7) | 0.1 (− 0.7 to 1.4) | 5.8 (0.7–26.7) | 3.9 (0.5–26.4) | 0.3 (− 3.7 to 21.0) | 8.8 (4.9–33.4) | 5.5 (2.3–29.0) | 3.0 (− 0.6 to 15.2) | 5.2 (0.2–33.4) | 4.5 (0.1–29.0) | 0.3 (− 3.7 to 21.0) |
Change from baseline at week 4 | n = 9 | n = 9 | n = 11 | n = 29 | ||||||||
Mean (SD) | − 0.7 (1.1) | − 0.6 (1.1) | NA | 0.3 (3.8) | 0.3 (3.0) | NA | − 0.3 (5.5) | 1.0 (4.0) | NA | − 0.2 (4.0) | − 0.1 (2.9) | NA |
Median (range) | − 0.5 (− 3.0 to 0.5) | − 0.5 (− 2.3 to 0.8) | 1.1 (− 5.8 to 6.0) | 0.1 (− 3.5 to 5.9) | − 0.5 (− 9.9 to 7.6) | 0.1 (− 8.9 to 5.4) | 0.0 (− 9.9 to 7.6) | 0.0 (− 8.9 to 5.9) |