Table 2 Information on lifestyle factors and medical data related to B12 in the study population
From: Vitamin B12 in Leber hereditary optic neuropathy mutation carriers: a prospective cohort study
Total n = 244 | LHON patients n = 147 | Asymptomatic LHON carriers n = 97 | p value | |
|---|---|---|---|---|
n (%#) | n (%#) | n (%#) | ||
(a) Total LHON cohort, stratified by LHON disease status | ||||
Smoking ever | 118 (48.6) | 79 (54.1) | 39 (40.2) | 0.034* |
Excessive alcohol consumption ever | 35 (14.5) | 31 (21.4) | 4 (4.2) | < 0.001*** |
Medications affecting B12 | 36 (15.2) | 27 (18.8) | 9 (9.7) | n.s |
Comorbidities affecting B12 | 10 (4.1) | 9 (6.2) | 1(1.0) | n.s |
Previous B12 supplementation | 19 (11.2) | 16 (16.8) | 3 (4.1) | 0.009** |
Lab abnormalities related to B12 | 73 (32.6) | 56 (41.2) | 17 (19.3) | 0.001** |
Polyneuropathy | 30 (12.7) | 26 (17.8) | 4 (4.6) | 0.003** |
Total n = 51 | LHON patients n = 30 | Asymptomatic LHON carriers n = 21 | p value | |
|---|---|---|---|---|
n (%#) | n (%#) | n (%#) | ||
(b) LHON cohort with B12 deficiency, stratified by LHON disease status | ||||
Smoking ever | 31 (60.8) | 21 (70.0) | 10 (47.6) | n.s |
Excessive alcohol consumption ever | 12 (24.0) | 11 (37.9) | 1 (4.8) | 0.007** |
Medications affecting B12 | 10 (20.8) | 6 (21.4) | 4 (20.0) | n.s |
Comorbidities affecting B12 | 2 (3.9) | 2 (6.7) | 0 (0.0) | n.s |
Previous B12 supplementation | 5 (21.7) | 4 (28.6) | 1 (11.1) | n.s |
Lab abnormalities related to B12 | 18 (38.3) | 14 (48.3) | 4 (22.2) | n.s |
Polyneuropathy | 8 (16.3) | 7 (23.3) | 1 (5.3) | n.s |
B12 deficiency | Yes n = 51 | No n = 193 | p value |
|---|---|---|---|
n (%#) | n (%#) | ||
(c) Total LHON cohort, stratified by presence of B12 deficiency | |||
Smoking ever | 31 (60.8) | 87 (45.3) | 0.049* |
Excessive alcohol consumption ever | 12 (24.0) | 23 (12.0) | 0.033* |
Medications affecting B12 | 10 (20.8) | 26 (13.8) | n.s |
Comorbidities affecting B12 | 2 (3.9) | 8 (4.2) | n.s |
Previous B12 supplementation | 5 (21.7) | 14 (9.6) | n.s |
Lab abnormalities related to B12 | 18 (38.3) | 73 (41.2) | n.s |
Polyneuropathy | 8 (16.7) | 22 (11.6) | n.s |