Fig. 2
From: Neuropsychology and MRI correlates of neurodegeneration in SPG11 hereditary spastic paraplegia
Brain volumetry in SPG11 patients relative to ADNI reference values. A Classical MRI signs of thin corpus callosum and cortical atrophy shown in an early, mildly affected SPG11 patient (individual #16 in Table 1; SPRS 16) and a severely affected SPG11 patient at an advanced stage of the disease (individual #4; SPRS 36). B Representative graphical depiction of volume z-scores of different cortical and subcortical regions of both patients. C–F Bar diagrams for different brain regions representing the proportional presence of a distinct structural phenotype, i.e. < 10% of age- and gender-matched control values derived from the ADNI control cohort