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Table 3 EORTC-QLQ-C30 symptom scales/items

From: Health-related quality of life and health literacy in patients with systemic mastocytosis and mast cell activation syndrome

Symptom burden

MCAS

SM

Control Group

Welch´s-F

MCAS vs. SM

MCAS vs. C

SM vs. C

N = 66

N = 32

N = 52

p Value*/Cohens´s d

p Value*/Cohen´s d

p Value*/Cohen´s d

Fatigue

86 ± 20

73 ± 26

15 ± 19

193.60**

0.041/0.59

 < 0.001/3.60

 < 0.001/2.61

Nausea and vomiting

39 ± 25

38 ± 28

2 ± 9

75.92**

0.979

 < 0.001/1.83

 < 0.001/1.91

Pain

75 ± 30

76 ± 28

9 ± 15

168.56**

0.999

 < 0.001/2.73

 < 0.001/3.19

Dyspnoea

62 ± 32

56 ± 36

10 ± 19

70.27**

0.758

 < 0.001/1.93

 < 0.001/1.75

Insomnia

71 ± 32

67 ± 31

17 ± 21

71.98**

0.776

 < 0.001/1.95

 < 0.001/1.97

Appetite loss

43 ± 37

27 ± 32

3 ± 10

40.46**

0.072

 < 0.001/1.40

 < 0.001/1.12

Constipation

43 ± 37

33 ± 35

6 ± 19

27.75**

0.394

 < 0.001/1.22

 < 0.001/1.04

Diarrhoea

53 ± 34

56 ± 33

6 ± 19

60.24**

0.896

 < 0.001/1.64

 < 0.001/1.97

Financal difficulties

42 ± 42

51 ± 41

0 ± 0

–***

0.568

 < 0.001/1.34

 < 0.001/2.00

  1. Significant p values and corresponding Cohen's d are marked in bold type
  2. Welch-ANOVA with *Games-Howell post-hoc test for calculation of p values between MCAS and SM, MCAS and Control Group, SM and control group; mean value ± standard deviation of the three groups; Cohen´s d as effect size; **Welch’s F p < 0.001; *** = cannot be calculated, because in at least one group a variance of 0 occurs; C = Control Group