Table 2 Clinical and somatic mutations in Langerhans cell histiocytosis
From: Langerhans cell histiocytosis in adolescent patients: a single-centre retrospective study
ID | Sex | Age (years) | Disease classification | Involved organ | Somatic mutations | EFS (months) | Disease status |
|---|---|---|---|---|---|---|---|
1 | M | 17 | MS | P,Lu,Li,Sp | BRAFN486_P490 | 31.4 | Stable |
2 | M | 15 | MS | P,Lu,Ty,LN | BRAFN486_P490,EGFRG721S | 4.0 | ReA |
3 | F | 17 | MS | P,Lu | BRAFN486_P490,TP53G206D | 25.6 | Stable |
4 | F | 16 | MS | Lu,Li,S,Sp,Ty | BRAFN486_P490 | 6.0 | ReA |
5 | M | 17 | SS-m | B | MAP2K1F53_Q58delinsL,MAPK1I211T | 27.0 | Stable |
6 | M | 14 | SS-s | B | BRAFN486_P490 | 23.6 | Stable |
7 | M | 15 | SS-m | B | BRAFV600E | 16.0 | Stable |
8 | M | 17 | SS-s | B | RUNX1R320X,TP53C176Y,SETBP1D868N | 5.0 | Stable |
9 | M | 16 | MS | B, Or | BRAFV600D, PTENR335X, NF1Q239X | 7.5 | Stable |
10 | M | 17 | SS-s | Lu | Not detected | 46.8 | ReA |