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Table 1 Cytogenetic findings of spontaneous and MMC-induced chromosome aberrations (breaks, radial forms) of examined patients 1 (IV.3) and 2 (IV.4) compared to healthy control group

From: Next-generation sequencing reveals novel variants and large deletion in FANCA gene in Polish family with Fanconi anemia

 

Spontaneous

MMC induced

Patient 1

Total cells

22 cells

50 cells

% Cells with breaks

14.00%

96.00%

Breaks/cell

0.14 br/cell

8.48 br/cell

Radial forms

None

65

Patient 2

Total cells

21 cells

50 cells

% Cells with breaks

0.00%

100.00%

Breaks/cell

0.00 br/cell

10.84 br/cell

Radial forms

None

107

Control

Total cells

20 cells

50 cells

% Cells with breaks

0.00%

4.00%

Breaks/cell

0.00 br/cell

0.05 br/cell

Radial forms

None

None

  1. br breaks