Variables | Proportion of Events | p value | Number of Events | p value | ||||
---|---|---|---|---|---|---|---|---|
Total (n = 44) n (%) | Severe (n = 19) n (%) | Moderate (n = 25) n (%) | Total (n = 44) (min–max) | Severe (n = 19) (min–max) | Moderate (n = 25) (min–max) | |||
Spontaneous bleeding (last 2 years) | 32 (0–97) | 49 (2–95) | 27 (0–97) | 0.157 | ||||
Bruises and ecchymosis | 18 (40.9) | 10 (52.6) | 8 (32.0) | 0.168 | 3 (1–12) | 1.5 (1–6) | 3.5 (2–12) | 0.016 |
Joint hemorrhage | ||||||||
Knee | 39 (88.6) | 16 (94.2) | 23 (92.0) | 0.638 | 12 (1–40) | 10 (2–32) | 12 (1–40) | 0.944 |
Ankle | 30 (68.2) | 14 (73.7) | 16 (64.0) | 0.495 | 3.5 (1–20) | 4 (1–20) | 3 (1–20) | 0.951 |
Elbow | 30 (68.2) | 14 (73.7) | 16 (64.0) | 0.495 | 9 (1–32) | 11 (2–32) | 8.5 (1–24) | 0.257 |
Wrist joint | 12 (27.9) | 7 (36.8) | 5 (20.8) | 0.245 | 3 (1–10) | 3 (1–8) | 3 (1–10) | 0.876 |
Hip joint | 13 (30.2) | 7 (36.8) | 6 (25.0) | 0.401 | 2 (1–12.0) | 1.5 (1–4) | 2 (2–12) | 0.394 |
Shoulders | 18 (41.9) | 6 (31.6) | 12 (50.0) | 0.224 | 2 (1–40) | 9.5 (1–40) | 2 (1–10) | 0.125 |
Muscle hemorrhage | ||||||||
Iliopsoas | 12 (27.9) | 6 (33.3) | 6 (24.0) | 0.712 | 1 (1–10) | 1.5 (1–10) | 1 (1–4) | 0.589 |
Buttock | 9 (20.9) | 3 (16.7) | 6 (24.0) | 0.361 | 2 (1–6) | 2 (2) | 1.5 (1–6) | 0.714 |
Calf muscle | 16 (37.2) | 7 (38.9) | 9 (36.0) | 0.847 | 1.5 (1–10) | 2 (1–10) | 1 (1–10) | 0.837 |
Thigh | 22 (50.0) | 10 (52.6) | 12 (48.0) | 0.761 | 2 (1–12) | 2 (1–8) | 2 (1–12) | 0.923 |
Flexor muscles of forearm | 11 (25.0) | 4 (21.1) | 7 (28.0) | 0.731 | 2 (1–10) | 5 (1–10) | 2 (1–6) | 0.412 |
Scalp | 1 (2.3) | – | 1 (4.0) | 1.000 | 1 | – | 1 | – |
Facial | 4 (9.1) | 2 (10.5) | 2 (8.0) | 1.000 | 1 (1–2) | 1 (1) | 1.5 (1–2) | 1.000 |
Mucosal bleeding | ||||||||
Gum bleeding | 22 (50.0) | 11 (57.9) | 11 (44.0) | 0.543 | 1 (1–10) | 4 (1–20) | 1 (1–20) | 0.243 |
Epistaxis | 6 (13.6) | 3 (15.8) | 3 (12.0) | 1.000 | 1 (1–10) | 1 (1–10) | 1 (1–2) | 1.000 |
Gastrointestinal bleeding | ||||||||
Hematemesis | 2 (4.5) | 1 (5.3) | 1 (4.0) | 1.000 | 2 (1–3) | 3 | 1 | 1.000 |
Melaena | 11 (25.0) | 5 (26.3) | 6 (24.0) | 1.000 | 2 (1–7) | 4 (1–7) | 1 (1–2) | 0.082 |
Oro-pharyngeal | 6 (13.6) | 2 (10.5) | 4 (16.0) | 0.684 | 3 (1–4) | 2.5 (1–4) | 3 (1–4) | 1.000 |
Retroperitoneal | 12 (27.3) | 5 (26.3) | 7 (28.0) | 0.901 | 1 (1–4) | 3 (2–4) | 1 (1–2) | 0.095 |
Hemoptysis | 3 (6.8) | 3 (15.8) | – | 0.073 | 2 (1–4) | 2 (1–4) | – | – |
Ocular bleeding | ||||||||
Subconjunctival hemorrhage | 5 (11.4) | 3 (15.8) | 2 (8.0) | 0.638 | 1 (1–2) | 1 (1–2) | 1 (1) | 0.800 |
Vitreous hemorrhage | 1 (2.3) | – | 1 (4.2) | 1.000 | – | – | – | – |
Genito-urinary bleeding | 16 (36.4) | 9 (47.4) | 7 (28.0) | 0.220 | 1 (1–5) | 1 (1–5) | 1 (1–2) | 0.470 |