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Table 4 Univariate and multivariate Cox regression of predictive factors for relapse in IgG4-RD

From: Clinical characteristics and therapeutic response of immunoglobulin G4-related disease: a retrospective study of 127 Chinese patients

Variable

Univariate analysis

Multivariate analysis

P value

Odds ratio

95% CI

P value

Odds ratio

95% CI

Demographics

Male, n (%)

0.10

5.29

0.69–40.32

   

Age at onset, years

0.64

0.93

0.94–1.04

   

Number of involved organs (≥ 5)

0.04

3.02

1.07–8.53

   

Lacrimal gland

0.14

1.54

0.86–2.73

   

Parotid

0.91

1.03

0.60–1.76

   

Submandibular gland

0.79

0.93

0.56–1.56

   

Lung

0.18

0.50

0.18–1.38

   

Retroperitoneal fibrosis

0.37

1.34

0.71–2.52

   

Pancreas

0.07

4.02

0.90–17.87

   

Bile duct

0.07

1.65

0.96–2.85

   

Lymph node

0.34

0.78

0.46–1.30

   

Kidney

0.34

1.67

0.58–4.83

   

IgG4, median (IQR), g/l

0.08

1.03

1.00–1.06

0.65

1.01

0.97–1.05

Serum IgG4 level ≥ 5 ULN

0.15

2.50

0.70–8.88

   

IgG4-RD RI scores

0.04

1.06

1.00–1.12

0.69

0.98

0.91–1.07

Score of ACR/EULAR IgG4-RD Classification Criteria

0.004

1.07

1.02–1.11

0.02

1.10

1.02–1.19

Score of ACR/EULAR IgG4-RD Classification Criteria ≥ 20

0.55

0.54

0.07–4.08

   

GC + IM therapy n (%)

0.04

0.12

0.02–0.93

0.06

0.14

0.02–1.06

Complete GC withdrawal

0.02

3.35

1.21–9.29

0.01

4.07

1.33–12.51

  1. IgG4, immunoglobulin G4; ACR/EULAR, American College of Rheumatology/European League Against Rheumatism; GC, glucocorticoids