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Table 1 Demographics and serological features for 127 IgG4-related disease patients divided by different clinical phenotype

From: Clinical characteristics and therapeutic response of immunoglobulin G4-related disease: a retrospective study of 127 Chinese patients

Characteristica

All patients (n = 127)

Pancreato-hepato-biliary (n = 59)

RPF/Aorta (n = 6)

Head and neck-limited (n = 15)

Mikulicz and systemic (n = 47)

P value

Male gender, n (%)

92 (72.4%)

47 (79.7%)

6 (100%)

7 (46.7%)

32 (68.1%)

0.03

Age at onset (years)

63 (55–69)

64.0 (55.0–69.0)

61.0 (55.8–65.5)

62.0 (54.0–72.0)

63.0 (56.0–70.0)

0.9

WBC (109/L)

5.7 (4.5–7.1)

5.5 (4.5–6.9)

9.6 (6.6–11.0)

6.1 (4.6–7.4)

5.5 (4.2–7.3)

0.02

Eosinophils (%)

4.4 (2.1–7.5)

4.5 (2.0–7.6)

3.3 (1.8–4.3)

4.3 (1.7–8.3)

4.5 (2.6–7.7)

0.7

ALT (U/L)

33.5 (15.0–134.8)

90 (32.0–175.0)

17.0 (12.8–35.3)

17 (14.0–24.5)

20.0 (12.8–83.3)

0.00

AST (U/L)

31.9 (19.8–91.3)

71.4 (26.0–130.5)

16.8 (15.3–22.2)

21.6 (18.8–25.7)

25.0 (18.3–81.5)

0.00

ALP (U/L)

102 (22.0–525.0)

316.5 (159.5–555.8)

98.0 (78.5–103.0)

76.0 (66.5–93.0)

79.0 (66.0–283.5)

0.00

GGT (U/L)

140.0 (74.0–392.0)

373.0 (70.0–817.0)

45.5 (32.3–88.8)

23.0 (17.0–31.0)

32.0 (15.0–236.0)

0.00

TBIL (umol/L)

35.9 (32.3–39.0)

53.9 (15.9–148.1)

9.8 (8.5–12.3)

10.8 (8.4–13.1)

14.5 (9.8–32.2)

0.00

DBIL (umol/L)

34.2 (30.3–40.6)

27.0 (4.4–98.0)

1.9 (1.5–2.7)

1.8 (1.5–2.3)

3.3 (1.9–12.9)

0.00

ALB (g/L)

18.2 (10.8–70.6)

35.5 (32.2–38.4)

38.2 (35.4–41.5)

38.6 (36.8–41.0)

35.7 (30.5–39.2)

0.03

GLO (g/L)

5.5 (2.1–37.0)

32.2 (29.5–37.7)

34.1 (29.7–40.0)

32.6 (30.0–42.8)

37.0 (32.3–48.6)

0.01

Cr (umol/L)

69.7 (58.1–84.2)

69.2 (54.8–77.5)

110.1 (79.8–140.1)

74.4 (62.5–91.0)

69.0 (56.8–89.5)

0.01

IgG (g/L)

1775 (1527–2357)

1680.0 (1475.0–2065.0)

1540 (1315.0–1870.0)

1545.0 (1240.0–2227.5)

2020.0 (1680.0–2850.0)

0.01

IgG4 (g/L)

9.8 (3.9–15.2)

10.3 (0.54–53.7)

3.0 (1.7–6.8)

8.2 (3.9–20.6)

13.0 (4.5–22.1)

0.01

IgG4-RD RI

8.0 (6.0–10.0)

6.0 (6.0–8.0)

10.0 (8.0–17.0)

6.0 (4.0–8.0)

10.0 (6.0–14.0)

0.00

  1. RPF, retroperitoneal fibrosis; WBC, white blood cell; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, glutamyl transpeptidase; TBIL, total bilirubin; DBIL, direct bilirubin; ALB, albumin; GLO, globulin; CR, Creatinine; IgG, immunoglobulin G; IgG4, immunoglobulin G4; IgG4-RD RI, IgG4-Related Disease Responder Index
  2. aAll continuous variables were shown as median (Interquartile range)