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Table 3 Therapeutic options in MPSs

From: Assessment, pharmacological therapy and rehabilitation management of musculoskeletal pain in children with mucopolysaccharidoses: a scoping review

Pharmacological management

Source

Publication date

Drug admnistered

Clarke et al. [27]

2009

Laronidase (ERT)

Burton e al. [28]

2015

Elosulfase alpha (ERT)

Robinson et al. [29]

2002

Pamidronate (biphosphonate)

Polgreen et al. [30]

2017

Adalimumab (TNF alpha inibitor)

Congedi et al. [31]

2018

NSAIDs, Acetaminophen, Opioids

Politei et al. [32]

2016

ERT, NSAIDs, Acetaminophen, Opioids

Felleiter et al. [33]

2005

NSAIDs, Acetaminophen, Opioids

Mozolewski et al. [34]

2017

Indomethacin plus Isoflavonoid

Hauer et al. [35]

2007

Anesthetics, Tryciclic Antidepressants, Anticonvulsivants

Hauer et al. [36]

2010

Anesthetics, Tryciclic Antidepressants, Anticonvulsivants

Harrison et al. [37]

2017

Marijuana (Cannabinoids)

Rehabilitation management

Source

Publication date

Rehabilitation therapies

Mishra et al. [48]

2017

Spinal Orthosis

Ravindran et al. [49]

2013

Complementary and Alternative medicine (CAM)

Vance et al. [50]

2014

Transcutaneous Electrical Nerve Stimulations (TENS)

Zhao et al. [51]

2008

Acupunture and Acupressure

Fisher et al. [52]

2018

Psychological Therapy

Winston et al. [53]

2005

Mindfullness, Excercises, Hypnosis, Educational programs, Biofeedback

Braun et al. [54]

2009

Animal-assisted therapy (AAT)

Kenny et al. [55]

 

Music therapy

Pharmacological/rehabilitation combined management

Source

Publication date

Treatments

Congedi et al. [31]

2018

ERT, NSAIDs, Opioids, Cannabinoids, Physical/Psychological interventions