Table 2 Data about pediatric population affected by MPS [4]
Authors | Patients | MPS | Musculoskeletal pain |
|---|---|---|---|
Brans et al | 89 adult and pediatric MPS subjects (55 of whom agreed to participate) | MPS I, MPS II, MPS III, MPS IV, MPS VI, MPS type unknown | 69% of children reported joint pain, mainly hip (27,8%) and back pain (25,9%). The highest frequency of pain was observed in MPS III group (52.9%) |
Hendriksz et al | Adult and pediatric MPS subjects with | Morquio A Syndrome (MPS IVA) | 64% of children reported joint pain (spinal area (63%), lower extremities (100%), upper extremities (69%), and head and neck area (56%)) |
Vijay and Wraith | 29 adult and pediatric MPS subjects | Attenuated MPSI phenotype | Progressive arthropathy (86%), fixed flexion deformity of the fingers (24%), and kyphosis, scoliosis, and/or lordosis (24%) |
White and Sousa | 18 pediatric MPS subjects | MPSIII | Many subjects requested orthopaedic evaluation of hip pain (hip dysplasia in 8 subjects; bilateral osteonecrosis of the femoral heads in 4 subjects) |
de Ruijter et al | 33 adult and pediatric MPS III subjects | MPS-3A, MPS-3B, MPS-3C | For 15 of the 33 subjects pain was indicated in one or both hips |