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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Patient-reported outcomes in a Chinese cohort of osteogenesis imperfecta unveil psycho-physical stratifications associated with clinical manifestations

Fig. 3

PCA and clustering analyses of child and adolescent PROMIS data. A Venn diagram showing the overlap of self and parental assessment cases. B Piechart showing the percentages of variance explained by principal component analysis (PCA). C A three-dimensional scatter plot showing the projections onto the top three components. Each dot represents one patient. D Scatter plot showing the first two PCs, with density contours. Red curves indicate saddle and valley between the two peaks/clusters. E Bar charts showing the ordered loading scores for the first and second PC. F Heatmap with clustering showing data in their original values. Marginal ridge plots show the marginal densities either per-patient (row-wise) or per PROMIS-item (column-wise), with an aggregated density for all data points placed on the top right corner. The meanings of the colors are explained by the smile or sad face symbols. The PROMIS items are abbreviated by their categories and a representative keyword. Refer to Additional file 1 for corresponding questions in full

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