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Table 1 Optimal application of decentralized trial design elements across study phases (+)

From: What role can decentralized trial designs play to improve rare disease studies?

Phase Online Recruitment Electronic Consent (Remote eConsent) Electronic Consent (On-Site eConsent) Electronic Patient Education + Engagement Electronic Clinical Outcome Assessments (eCOAs) Telehealth Wearable Sensors Home Health Visits by Healthcare Professionals Drug Supply by Mail
Natural History Study/Registry + +   + + + +   
First in Human/Ph1    + + + +    
Phase II/III +   + + + + + + +
Open Label Extension   +   + + + + + +
Post-Approval Observational + +   + + + +   
Long-Term Followup   +   + + + +   
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172