Analysis of the genotypic profile and its relationship with the clinical manifestations in people with cystic fibrosis: study from a rare disease registry

Table 4 Multivariate analysis for the clinical manifestations of people with cystic fibrosis and their genotype*

Variables	Genotype
Variables	Unadjusted			Adjusted
	OR	95% CI	p-value	OR	95% CI	p-value
%FEV₁**	1.8	0.73–3.84	0.226	5.3	1.15–24.41	0.032
S. Aureus infection	1.9	0.92–3.77	0.084	1.8	0.76–4.44	0.174
MRSA infection	3.2	0.70–14.86	0.136	2.6	0.35–18.97	0.350
Pseudomonas aeruginosa infection	1.8	0.81–3.84	0.155	7.5	1.72–33.00	0.007
Achromobacter xylosoxidans infection	4.5	0.99–20.87	0.052	5.1	0.72–35.42	0.103
Meconium ileus	4.7	1.19–18.64	0.028	3.2	0.71–14.50	0.132
Pancreatic insufficiency	17.2	7.57–39.01	< 0.001	28.1	9.33–84.44	< 0.001
Liver disease	3.7	0.98–14.30	0.053	3.9	0.72–20.61	0.115
CF-related diabetes	3.5	3.52–13.51	0.067	3.4	0.78–15.12	0.102

Adjusted model controlled by age at diagnosis and through December 31 2018, sex and native country of the parents
*Results for high-risk genotype using low risk genotype as a reference
**Dichotomized in ≤ 90% and > 90%

ISSN: 1750-1172