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Table 2 Clinical characteristics of the patients according to serum Ca concentration

From: Analysis of 55 patients with multiple endocrine neoplasia type 1-associated insulinoma from a single center in China

 

Hypercalcemia

n = 24

Normocalcemia

n = 18

P value

Gender, male, n (%)

13 (59%)

9 (41%)

1

Height, cm, mean ± SD

164.19 ± 12.02

165.35 ± 8.66

0.738

Weight, kg, mean ± SD

66.38 ± 12.76

70.81 ± 14.1

0.265

BMI, kg/m2, median (IQR)

22.45 (20.49–26.88)

26.33 (23.67–28.6)

0.057

Ca, mmol/L, mean ± SD

2.75 ± 0.2

2.43 ± 0.13

 < 0.001**

iCa, mmol/L, median (IQR)

1.35 (1.32–1.45)

1.21 (1.19–1.22)

0.002**

Albumin, g/L, mean ± SD

41.43 ± 4.93

43.94 ± 3.78

0.082

PTH, pg/mL, median (IQR)

147.35 (75.55–270)

48.3 (33.35–75.3)

0.001**

P, mmol/L, median (IQR)

0.94 (0.8–1.22)

1.04 (0.98–1.36)

0.044*

Age, years , mean ± SD at

   

 Initial symptoms

31.88 ± 16.36

28.17 ± 11.53

0.417

 Insulinoma diagnosis

36.63 ± 17.06

31.67 ± 12.47

0.304

 MEN1 diagnosis

38.50 ± 15.41

31.67 ± 12.47

0.131

Delay of diagnosis of, median (IQR), years

   

 Insulinoma

2 (1–6)

2.5 (1–3.25)

0.777

 MEN1

6 (2.25–11)

2.5 (1–4.75)

0.045*

Hypoglycemia related indexes, mean ± SD

   

 Glucose, mmol/L

2.35 ± 0.59

2.18 ± 0.47

0.329

 Insulin, μIU/mL

14.49 (6.83–23.15)

51.14 (33.65–71.54)

< 0.001**

 C-peptide, ng/mL

3.09 ± 1.7

4.11 ± 1.78

0.085

 INS/GLU

5.77 (2.71–13.1)

22.58 (13.68–29.98)

 < 0.001**

 C-P/GLU

1.38 ± 0.91

1.95 ± 1.04

0.081

Matsuda-ISI, mean ± SD

73.72 ± 42.35

59.68 ± 43.7

0.414

Number of pNETs, n (%)

   

 Multiple

20 (83.3%)

10 (55.6%)

0.104

 Single

4 (16.7%)

8 (44.4%)

 

Maximum diameter of pNETs, cm, mean ± SD

2.31 ± 1.17

1.92 ± 0.58

0.112

Tumor grade, n (%)

   

 Grade 1

8 (61.5%)

11(68.8%)

0.714

 Grade 2

5 (38.5%)

5(31.2%)

 

Histopathological Ki67% of surgery samples biopsy,%, mean ± SD

2.82 ± 1.83

2.22 ± 1.3

0.894

Mitotic figures,%, median (IQR)

1 (1–4)

2 (1–3)

0.776

  1. BMI, Body Mass Index; Ca, calcium; iCa, Ionized-Ca; PTH, parathyroid hormone; P, phosphorus; MEN-1, multiple endocrine neoplasia type 1; INS, insulin; GLU, glucose; C-P, C-peptide; Matsuda-ISI, Matsuda-Insulin Sensitivity Index
  2. *p < 0.05, **p < 0.01