Table 1 Characteristics of MEN1 patients with insulinoma
Overall (n = 55) | |
|---|---|
Gender, male, n (%) | 29 (52.7%) |
Height, cm, mean ± SD | 165.04 ± 9.71 |
Weight, kg, mean ± SD | 68.63 ± 13.49 |
BMI, kg/m2 mean ± SD | 25.16 ± 4.15 |
Age, years, mean ± SD at | |
Initial hypoglycemia | 30.76 ± 14.03 |
Insulinoma diagnosis | 34.49 ± 14.99 |
MEN1 diagnosis | 36.20 ± 14.08 |
Delay of diagnosis of, years, median (IQR) | |
Insulinoma | 2 (1–5) |
MEN1 | 4 (1–10) |
Follow-up period, years, mean ± SD | 5.75 ± 5.31 |
During hypoglycemic episodes, mean ± SD | |
Glucose, mmol/L | 2.25 ± 0.56 |
Insulin, μIU/mL | 23.77 (10.52–47.82) |
C-peptide, ng/mL | 3.38 ± 1.79 |
INS/GLU | 8.54(4.21–20.45) |
C-peptide/GLU | 1.53 ± 1.00 |
Ca, mmol/L, mean ± SD | 2.61 ± 0.24 |
iCa, mmol/L, median (IQR) | 1.33 (1.22–1.37) |
Albumin, g/L, mean ± SD | 42.19 ± 4.46 |
PTH, pg/mL, median (IQR) | 110 (55.23–187.20) |
P, mmol/L, median (IQR) | 0.99 (0.86–1.29) |
Matsuda-ISI, mean ± SD | 73.72 ± 42.35 |
Number of pNETs, n (%) | |
Multiple | 38 (69.1%) |
Single | 17(30.9%) |
Location of pNETs, n (%) | |
Head/neck | 21 (38.2%) |
Body/tail | 19 (34.5%) |
Head/neck and Body/tail | 15 (27.3%) |
Maximum diameter of pNETs, cm, mean ± SD | 2.41 ± 1.44 |
Lymph nodes removal at initial surgery, n (%) | 8 (16%) |
Lymph node metastases at initial surgery, n (%) | 1 (2%) |
Liver metastases | 1 (2%) |
Tumor grade, n (%) | |
Grade 1 | 24 (63.2%) |
Grade 2 | 14 (36.8%) |
Histopathological Ki67% of surgery samples biopsy, %, mean ± SD | 2.87 ± 1.94 |
Mitotic figures, %, median (IQR) | 2 (1–3.25) |