Table 3 Impact coverage in existing HAE-specific instruments
IMPACT—content coverage of existing HAE specific instruments | AE-QoL 17 items | HAE-PRO 18 items | AECT 4 items | AAS 5 items | HAE-AS 12 items | HAE-QoL 25 items | HAEA-QoL 27 items |
|---|---|---|---|---|---|---|---|
Ability to work/productivity | Yes | Yes | Yes | Yes | |||
Ability to do physical activity | Yes | ||||||
Ability to carry out daily activities | Yes | Yes | Yes | ||||
Leisure time | Yes | Yes | |||||
Social relationships | Yes | Yes | Yes | ||||
Eating and drinking restricted | Yes | ||||||
Sleep difficulties | Yes | ||||||
Tired during the day | Yes | ||||||
Trouble concentrating | Yes | ||||||
Burden experienced by swelling | Yes | ||||||
Ability to go to school | Yes | ||||||
Going out in public | Yes | ||||||
Ability to travel | Yes | Yes | |||||
ER visit due to HAE attack | Yes | ||||||
HAE controlled by treatment | Yes | ||||||
Worry about aspects of care and treatment | Yes | ||||||
Bothered from unpredictability of HAE attack | Yes | ||||||
General health | Yes | Yes | |||||
General quality of life | Yes | ||||||
Bothered from unpredictability of HAE attack | Yes | ||||||
Emotional impacts | |||||||
Feeling of enjoying life | Yes | ||||||
Mood/depression | Yes | Yes | |||||
Anxiety/fear/worry | Yes | Yes | Yes | ||||
Embarrassment/shame (appearance) | Yes | Yes | Yes | ||||
Recall period | Last 4 weeks | None defined | Past 3 weeks | Past 24 h | Past 6 months | Past 6 months | None defined |