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Table 2 Demographics of asymptomatic gene carriers according to genotype category

From: Clinical and genetic profile of patients enrolled in the Transthyretin Amyloidosis Outcomes Survey (THAOS): 14-year update

 

Overall (n = 1830)

Val30Met (n = 1339)

Cardiac mutations (n = 200)

Non-Val30Met excluding cardiac (n = 291)

Male, n (%)

776 (42.4)

514 (38.4)

115 (57.5%)

147 (50.5)

Race/ethnicitya, n (%)

    

 Caucasian

677 (77.9)

384 (87.3)

113 (60.1)

180 (74.7)

 African descent

103 (11.9)

27 (6.1)

68 (36.2)

8 (3.3)

 American Hispanic

11 (1.3)

7 (1.6)

2 (1.1)

2 (0.8)

 Latino American

40 (4.6)

8 (1.8)

5 (2.7)

27 (11.2)

 Asian

33 (3.8)

12 (2.7)

0

21 (8.7)

 Other

5 (0.6)

2 (0.5)

0

3 (1.2)

Age at enrollment (years), mean (SD)

42.4 (15.7)

39.3 (14.5)

57.3 (16.1)

46.0 (14.1)

  1. Cardiac mutations include Val122Ile, Leu111Met, Thr60Ala, and Ile68Leu
  2. aDenominator for race/ethnicity is the total of non-missing records
  3. SD = standard deviation