Overall (n = 3779) | ATTRwt amyloidosis (n = 1156) | Val30Met early onset (n = 826) | Val30Met late onset (n = 588) | Cardiac mutations (n = 384) | Non-Val30Met excluding cardiac (n = 697) | |
---|---|---|---|---|---|---|
Male, n (%) | 2698 (71.4) | 1086 (93.9) | 447 (54.1) | 381 (64.8) | 284 (74.0) | 429 (61.5) |
Race/ethnicitya, n (%) | ||||||
Caucasian | 2083 (76.6) | 961 (94.4) | 183 (67.3) | 336 (86.6) | 157 (46.0) | 397 (65.4) |
African descent | 269 (9.9) | 30 (2.9) | 26 (9.6) | 16 (4.1) | 164 (48.1) | 28 (4.6) |
American Hispanic | 15 (0.6) | 1 (0.1) | 8 (2.9) | 0 | 2 (0.6) | 3 (0.5) |
Latino American | 124 (4.6) | 5 (0.5) | 18 (6.6) | 4 (1.0) | 15 (4.4) | 78 (12.9) |
Asian | 218 (8.0) | 15 (1.5) | 37 (13.6) | 31 (8.0) | 2 (0.6) | 99 (16.3) |
Other | 11 (0.4) | 6 (0.6) | 0 | 1 (0.3) | 1 (0.3) | 2 (0.3) |
Age at enrollment (years), mean (SD) | 62.3 (17.0) | 77.5 (7.1) | 39.8 (7.9) | 67.9 (8.3) | 69.3 (9.1) | 56.9 (12.6) |
Age at onset of ATTR amyloidosis symptoms (years), n | 3775 | 1156 | 826 | 588 | 383 | 694 |
Mean (SD) | 56.3 (17.8) | 72.0 (9.7) | 33.1 (6.5) | 61.8 (9.3) | 63.5 (11.3) | 50.9 (12.6) |
Time from symptom onset to diagnosis (years), n | 3492 | 1092 | 826 | 588 | 347 | 639 |
Mean (SD) | 4.0 (5.9) | 4.7 (6.9) | 2.0 (3.0) | 4.4 (5.0) | 4.6 (6.7) | 4.6 (6.5) |
Follow-up timeb (years), mean (SD) | 3.6 (3.0) | 2.0 (1.8) | 6.2 (3.0) | 3.9 (2.7) | 2.4 (2.2) | 3.1 (2.6) |