Fig. 4

Distribution of phenotype at enrollment in symptomatic patients according to genotype category. The proportions of patients with each phenotype are shown by genotype. The sum of values for each genotype equals one. Val30Met early onset and late onset n based on all patients with available data for disease diagnosis; 128 patients with the Val30Met mutation and no date of diagnosis were not included. Cardiac mutations include Val122Ile, Leu111Met, Thr60Ala, and Ile68Leu. ATTRwt amyloidosis = wild-type transthyretin amyloidosis