Fig. 1From: Do patients with Prader–Willi syndrome have favorable glucose metabolism?The hypothesized mechanism underlying the effects of loss of necdin expression on adipose tissue in PWS. Adipogenic differentiation is promoted, thus leading to lower pre-adipocyte and higher adipocyte content. Adipocytes of PWS patients are insensitive to lipolytic stimulation, leading to accumulation of triglyceridesBack to article page