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Table 4 Regressions predicting anxiety and depression in adults with RDs

From: Healthcare access, satisfaction, and health-related quality of life among children and adults with rare diseases

Step Predictor Anxiety Depression
b SE Sig. Bootstrapped 95% confidence interval b SE Sig. Bootstrapped 95% confidence interval
Lower Upper Lower Upper
1 Nonbinary (dummy coded 1 = nonbinary) 8.40 3.37 0.00 1.95 15.46 5.59 4.34 0.14 − 1.03 15.72
  Gender (dummy coded 1 = female) 2.00 0.99 0.05 − 0.01 4.17 0.97 0.91 0.29 − 0.73 2.93
  Race/ethnicity (1 = white, 2 = person of color) 0.18 1.50 0.90 − 2.94 2.93 − 1.30 1.49 0.37 − 4.14 1.58
  Income − 0.65 0.21 0.00 − 1.06 − 0.25 − 1.10 0.21 0.00 − 1.50 − 0.67
  Age − 0.13 0.03 0.00 − 0.18 − 0.08 − 0.08 0.03 0.00 − 0.13 − 0.03
2 Nonbinary (dummy coded 1 = nonbinary) 5.48 3.43 0.07 − 1.50 12.47 2.25 3.71 0.54 − 3.60 10.56
  Gender (dummy coded 1 = female) − 0.26 0.87 0.76 − 1.93 1.53 − 0.97 0.81 0.23 − 2.46 0.65
  Race/ethnicity (1 = white, 2 = person of color) − 0.79 1.33 0.55 − 3.46 1.79 − 2.73 1.22 0.02 − 5.17 − 0.23
  Income − 0.33 0.19 0.07 − 0.68 0.05 − 0.71 0.18 0.00 − 1.05 − 0.34
  Age − 0.10 0.02 0.00 − 0.15 − 0.05 − 0.05 0.02 0.00 − 0.10 − 0.01
  RD number − 0.18 0.86 0.83 − 1.72 1.64 − 0.34 0.78 0.65 − 1.82 1.23
  Time since diagnosis − 0.06 0.04 0.10 − 0.14 0.01 − 0.01 0.04 0.84 − 0.08 0.07
  Progressive course (dummy coded 1 = progressive) 1.88 0.90 0.04 − 0.04 3.64 0.49 0.88 0.55 − 1.18 2.35
  Episodic course (dummy coded 1 = episodic) 2.84 1.07 0.01 0.87 5.03 0.55 1.00 0.61 − 1.47 2.56
  Improving course (dummy coded 1 = improving) 3.69 3.03 0.17 − 1.53 10.07 3.70 4.15 0.36 − 2.60 12.73
  Sleep disturbance 0.18 .046c 0.00 0.09 0.27 0.16 0.05 0.00 0.07 0.26
  Physical function 0.09 0.05 0.07 0.00 0.18 0.00 0.05 0.93 − 0.09 0.08
  Pain interference 0.07 0.04 0.08 − 0.01 0.15 0.02 0.04 0.59 − 0.06 0.10
  Ability to participate in social roles 0.22 0.06 0.00 0.11 0.33 0.29 0.05 0.00 0.19 0.40
  Fatigue 0.18 0.04 0.00 0.10 0.26 0.20 0.04 0.00 0.13 0.28
3 Nonbinary (dummy coded 1 = nonbinary) 4.89 3.23 0.08 − 1.49 11.62 1.66 3.75 0.66 − 4.32 9.96
  Gender (dummy coded 1 = female) − 0.24 0.86 0.78 − 1.87 1.51 − 0.95 0.79 0.23 − 2.38 0.64
  Race/ethnicity (1 = white, 2 = person of color) − 0.76 1.33 0.56 − 3.44 1.81 − 2.70 1.20 0.02 − 5.00 − 0.25
  Income − 0.23 0.18 0.21 − 0.59 0.12 − 0.61 0.18 0.00 − 0.96 − 0.25
  Age − 0.08 0.02 0.00 − 0.13 − 0.03 − 0.03 0.02 0.12 − 0.08 0.01
  RD number − 0.46 0.84 0.61 − 2.09 1.34 − 0.62 0.77 0.42 − 2.11 0.94
  Time since diagnosis − 0.07 0.03 0.03 − 0.14 − 0.01 − 0.02 0.03 0.59 − 0.08 0.05
  Progressive course (dummy coded 1 = progressive) 1.79 0.88 0.05 − 0.10 3.50 0.40 0.87 0.62 − 1.29 2.28
  Episodic course (dummy coded 1 = episodic) 2.57 1.04 0.02 0.58 4.72 0.28 0.99 0.79 − 1.72 2.18
  Improving course (dummy coded 1 = improving) 4.51 1.87 0.01 0.81 8.29 4.49 2.13 0.02 0.45 8.85
  Sleep disturbance 0.17 0.05 0.00 0.08 0.26 0.15 0.05 0.00 0.06 0.24
  Physical function 0.12 0.05 0.02 0.02 0.21 0.02 0.05 0.63 − 0.07 0.11
  Pain interference 0.06 0.04 0.13 − 0.02 0.14 0.01 0.04 0.78 − 0.07 0.09
  Ability to participate in social roles 0.15 0.06 0.01 0.04 0.26 0.22 0.05 0.00 0.11 0.32
  Fatigue 0.17 0.04 0.00 0.09 0.25 0.19 0.04 0.00 0.12 0.26
  Stigma 0.26 0.06 0.00 0.15 0.38 0.26 0.06 0.00 0.14 0.37
  1. Standard errors and confidence intervals based on 1000 bootstrap samples