PROS condition | Clinical characteristics |
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Overgrowth (lipomatous, spinal/paraspinal, bony, limb and digit); cutaneous and vascular malformations (lymphatic, venous, capillary ± arteriovenous malformations); varicose embryonic veins and blood clots; musculoskeletal abnormalities; visceral abnormalities; neurologic abnormalities | |
Vascular malformations (capillary, venous, ± lymphatic malformations) or varicose embryonic veins and blood clots; hypertrophy of bone and soft tissue (features are typically isolated to the pelvis and a lower extremity, but upper extremities and other organs can be involved) | |
Segmental overgrowth of brain tissue (megalencephaly or hemimegalencephaly); cutaneous capillary malformations with focal or generalized somatic overgrowth; digital anomalies; tone abnormalities; mild to severe intellectual disability may be present |