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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: UPRmt activation improves pathological alterations in cellular models of mitochondrial diseases

Fig. 3

Protein expression levels under tetracycline treatment. a Western blot analysis of the mutated protein (EF-G1) and several mitochondrial complex proteins after tetracycline treatment in mutant GFM1 cells. Control and mutant GFM1 cells were treated with 10 µM tetracycline for 7 days. Cells were seeded in glucose-rich medium. A representative actin band is shown for each assay, although loading control was checked for every Western blot. b Band densitometry of the western blot. c Normalization of band densitometry versus VDAC. Data represents the mean ± SD of 3 independent experiments. *p < 0.05 between control and mutant GFM1 cells; ap < 0.05 between non-treated mutant GFM1 and treated mutant GFM1 cells; $p < 0.05 between untreated and treated control cells. A.U., arbitrary units. KDa=Kilodalton, kDa

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