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Table 2 Time for initiation and time for abrogation of thromboprophylaxis in patients with Cushing’s syndrome

From: Current clinical practice for thromboprophylaxis management in patients with Cushing’s syndrome across reference centers of the European Reference Network on Rare Endocrine Conditions (Endo-ERN)

Characteristic

Total number of RCs (N = 23)

Time for initiation of thrombo-prophylaxisa

From diagnosis onwards

11 (48%)

X days preoperatively (mean):

4 (17%)

 X = 7

1/4 (25%)

 X = 14

1/4 (25%)

 X = 18

1/4 (25%)

 Not specified

1/4 (25%)

Start on the day before/of the surgery

6 (26%)

X days postoperatively (mean):

3 (13%)

 X = 1

2/3 (67%)

 X = 3

1/3 (33%)

Other: varies, depends on presentation

2 (9%)

Time for abrogation of thrombo-prophylaxis

Standardized

8 (35%)

Stop 1 week before until 2 weeks after surgery

1/8 (13%)

Stop between 4 and 6 days postoperatively

1/8 (13%)

Stop between 2 and 4 weeks postoperatively

2/8 (25%)

Stop at 1 month postoperatively

3/8 (38%)

Stop at 3 months postoperatively

1/8 (13%)

Individualizeda

15 (65%)

Stop upon achieving remission according to normalization of cortisol production

6/15 (40%)

As soon as the patient is no longer immobile

9/15 (60%)

Based upon hemostatic parameters

1/15 (7%)

Other: Varies, depends on patient status, improvement of clinical parameters and/or risk factors

4/15 (27%)

  1. RC reference center
  2. aNot mutually exclusive