Fulfillment status of hypertriglyceridemia and hypofibrinogenemia in children with hemophagocytic lymphohistiocytosis and risks of multiple organ dysfunction syndrome and early mortality

Table 1 Distribution of the worst values for triglyceride and fibrinogen among 117 pediatric HLH patients

Worst value during hospitalization	All (n = 117)	MODS			30-day survival
Worst value during hospitalization	All (n = 117)	No (n = 46)	Yes (n = 71)	P	Survive (n = 78)	Death (n = 36)	P
Triglyceride, mmol/L
Median (Q1, Q3)	4.08 (3.01, 5.45)	4.30 (3.59, 6.16)	3.72 (2.64, 4.93)	0.0069	4.31 (3.35, 6.11)	3.47 (2.16, 4.41)	0.0028
Min, max	1.05, 11.41	1.81, 11.41	1.05, 11.15		1.81, 11.41	1.05, 10.44
< 3.0 mmol/L, n (%)	29 (24.8)	4 (8.7)	25 (35.2)	0.0012	12 (15.4)	16 (44.4)	0.0019
≥ 3.0 mmol/L, n (%)	88 (75.2)	42 (91.3)	46 (64.8)		66 (84.6)	20 (55.6)
Fibrinogen, mg/dL
Median (Q1, Q3)	83 (60, 122)	113.50 (68, 159)	69 (60, 101)	0.0004	88.5 (61, 124)	65.5 (60, 108)	0.0481
Min, max	44, 349	44, 349	51, 256		44, 229	51, 349
> 150 mg/dL, n (%)	18 (15.4)	13 (28.3)	5 (7.0)	0.0019	13 (16.7)	3 (8.3)	0.3842
≤ 150 mg/dL, n (%)	99 (84.6)	33 (71.7)	66 (93.0)		65 (83.3)	33 (91.7)

HLH, hemophagocytic lymphohistiocytosis; MODS, multiple organ dysfunction syndrome
Values in bold are statistically significant (P < 0.05)

ISSN: 1750-1172