Table 1 Clinical characteristics

Demography

Age (years)

45.0 [36.0–58.0]

49.5 [33.5–62.0]

42.0 [37.0–57.0]

–

Age (\(\ge\)60)*

64 (22.6%)

48 (30.4%)

16 (12.8%)

\(p<0.001\)

Sex (male)*

128 (45.2%)

80 (50.6%)

48 (38.4%)

\(p=0.042\)

Comorbidities

Chronic cardiovascular disease*

55 (19.4%)

46 (29.1%)

9 (7.2%)

\(p<0.001\)

Chronic kidney disease*

41 (14.5%)

36 (22.8%)

\(\le\)5 (\(\le\)4.0%)#

\(p<0.001\)

Malignant neoplasm*

30 (10.6%)

23 (14.6%)

7 (5.6%)

\(p=0.019\)

Moderate or severe liver disease

7 (2.5%)

\(\le\)5 (\(\le\)3.2%)

\(\le\)5 (\(\le\)4.0%)

–

Obesity (Clinician defined)

62 (21.9%)

35 (22.2%)

27 (21.6%)

–

Chronic pulmonary disease*

49 (17.3%)

35 (22.2%)

14 (11.2%)

\(p=0.018\)

Diabetes (Type 1 and 2)

33 (11.7%)

19 (12.0%)

14 (11.2%)

–

Number of COVID-19 related comorbidities (\(\ge\)2)*

79 (27.9%)

60 (38.0%)

19 (15.2%)

\(p<0.001\)

Rare disease groups

Neurology and neurodevelopmental disorders

66 (23.3%)

66 (41.8%)

–

–

Renal and urinary tract disorders

26 (9.2%)

26 (16.5%)

–

–

Cardiovascular disorders

20 (7.1%)

20 (12.7%)

–

–

Ophthalmological disorders

12 (4.2%)

12 (7.6%)

–

–

Other groups

34 (12.0%)

34 (21.5%)

–

–

Rare disease—Specific diseases

Epilepsy plus other features

18 (6.4%)

18 (11.4%)

–

–

Cystic kidney disease

11 (3.9%)

11 (7.0%)

–

–

Intellectual disability

10 (3.5%)

10 (6.3%)

–

–

Hereditary ataxia

10 (3.5%)

10 (6.3%)

–

–

Unexplained kidney failure in young people

6 (2.1%)

6 (3.8%)

–

–

Ultra-rare undescribed monogenic disorders

6 (2.1%)

6 (3.8%)

–

–

Rod-cone dystrophy

6 (2.1%)

6 (3.8%)

–

–

Other diseases

23 (14.6%)

20 (12.7%)

–

–