Differential humanistic and economic burden of mild, moderate and severe haemophilia in european adults: a regression analysis of the CHESS II study

Table 2 Average marginal effects for annual direct medical and societal costs and HRQoL scores (EQ-5D-5L)

Model parameter	Direct costs Sample, n = 707	Societal costs Sample, n = 286	HRQoL (EQ-5D-5L) Sample, n = 290
Severity, vs Mild
Moderate	€ 2469 P < 0.001	€ 2825 P < 0.01	−0.089 P < 0.001
Severe	€ 3105 P < 0.001	€ 11,115 P < 0.001	−0.105 P < 0.001
Age, years	€ 14	€ 86	0.001
Body mass index, kg/m²	€ −48.32	€ 881 P < 0.01	−0.003
Country, vs Germany
Italy	€ 1643 P < 0.001	€ 8727 P < 0.001	−0.060
Spain	€ 3274 P < 0.001	€ 12,362 P < 0.001	−0.035
France	€ −633 P < 0.05	€ 5063	0.031
United Kingdom	€ 1478 P < 0.001	€ −319	−0.007
Romania	€ −956 P < 0.05	NA	NA
Comorbidities, vs none
1	€ 547	€ 1616	−0.063 P < 0.01
≥ 2	€ 1750 P < 0.001	€ 5736 P < 0.05	−0.111 P < 0.01
Factor consumption per kg	€ 0.198 P < 0.001	€ 1.18 P < 0.01	−5.34 × 10⁻⁶
Education, vs Primary
Secondary/vocational	–	–	0.04
Tertiary			0.09

Cost models adjusted for haemophilia severity (base outcome: mild), age, BMI, country (base outcome: Germany), comorbidities (base outcome: 0 comorbidities) and weight-adjusted factor consumption; health status model also adjusted for education level (base outcome: primary)
NA not available
Direct medical and societal costs are captured at patient level for a period of 12 months
Statistical significance is indicated in italics: P < 0.001; P < 0.01; P < 0.05. P > 0.05 for all other differences

ISSN: 1750-1172