Table 1 Demographic and clinical characteristics of the analytic sample from CHESS II
Characteristic | Direct costs Sample, n = 707 | Societal costs Sample, n = 286 | HRQoL (EQ-5D-5L) Sample, n = 290 |
|---|---|---|---|
Age, mean (SD) | 38.4 (14.2) | 38.5 (14.7) | 38.5 (14.7) |
BMI, n (%) | |||
Underweight | 12 (2) | 0 | 0 |
Normal weight | 399 (56) | 166 (58) | 169 (58) |
Overweight | 276 (39) | 113 (40) | 114 (39) |
Obese | 20 (3) | 7 (20) | 7 (2) |
Country, n (%) | |||
Italy | 279 (39) | 119 (42) | 120 (41) |
Spain | 225 (32) | 113 (40) | 112 (39) |
United Kingdom | 76 (11) | 14 (5) | 16 (6) |
France | 68 (10) | 34 (12) | 36 (12) |
Germany | 49 (7) | 6 (2) | 6 (2) |
Romania | 10 (1) | 0 | 0 |
Haemophilia type, n (%) | |||
A | 574 (81) | 245 (86) | 250 (86) |
B | 133 (19) | 41 (14) | 40 (14) |
Severity, n (%) | |||
Mild | 110 (16) | 44 (15) | 46 (16) |
Moderate | 264 (37) | 87 (30) | 90 (31) |
Severe | 333 (47) | 155 (54) | 154 (53) |
Comorbidities, n (%) | |||
0 | 420 (59) | 175 (61) | 178 (61) |
1 | 157 (22) | 66 (23) | 65 (22) |
≥ 2 | 130 (18) | 45 (16) | 47 (16) |
Treatment*, n (%) | |||
Overall | n = 707 | n = 286 | n = 290 |
No treatment | 261 (37) | 91 (32) | 94 (32) |
On-demand | 87 (12) | 32 (11) | 35 (12) |
Prophylaxis | 359 (51) | 163 (57) | 161 (56) |
Mild | n = 110 | n = 44 | n = 46 |
No treatment | 77 (70) | 30 (68) | 30 (65) |
On-demand | 7 (6) | 0 | 1 (2) |
Prophylaxis | 26 (24) | 14 (32) | 15 (33) |
Moderate | n = 264 | n = 87 | n = 90 |
No treatment | 184 (70) | 61 (70) | 64 (71) |
On-demand | 25 (9) | 8 (9) | 9 (10) |
Prophylaxis | 55 (21) | 18 (21) | 17 (19) |
Severe | n = 333 | n = 155 | n = 154 |
No treatment | 0 | 0 | 0 |
On-demand | 55 (17) | 24 (15) | 25 (16) |
Prophylaxis | 278 (83) | 131 (85) | 128 (84) |
1-year factor replacement therapy consumption, IU/kg, mean (SD) | 1232.4 (2211.1) | 1635.5 (2646.9) | 1583.7 (2624.8) |
Annual bleeding rate, n (%) | |||
Overall | n = 707 | n = 286 | n = 290 |
0 | 88 (12) | 26 (9) | 26 (9) |
1 to 5 | 538 (76) | 217 (76) | 218 (75) |
≥ 5 | 105 (15) | 43 (15) | 46 (16) |
Mild | n = 110 | n = 44 | n = 46 |
0 | 30 (27) | 9 (20) | 9 (20) |
1 to 5 | 79 (72) | 35 (80) | 37 (80) |
≥ 5 | 1 (1) | 0 | 0 |
Moderate | n = 264 | n = 87 | n = 90 |
0 | 33 (13) | 9 (10) | 9 (10) |
1 to 5 | 191 (72) | 69 (79) | 71 (78) |
≥ 5 | 40 (15) | 9 (10) | 11 (12) |
Severe | n = 333 | n = 155 | n = 154 |
0 | 24 (7) | 8 (5) | 8 (5) |
1 to 5 | 254 (76) | 113 (73) | 111 (73) |
≥ 5 | 55 (17) | 34 (22) | 34 (22) |
Number of problem joints, n (%) | |||
Overall | n = 707 | n = 286 | n = 290 |
0 | 445 (63) | 177 (62) | 177 (61) |
≥ 1 | 262 (37) | 109 (38) | 113 (39) |
Mild | n = 110 | n = 44 | n = 46 |
0 | 34 (77) | 34 (77) | 36 (78) |
≥ 1 | 10 (23) | 10 (23) | 10 (22) |
Moderate | n = 264 | n = 87 | n = 90 |
0 | 168 (64) | 58 (67) | 58 (64) |
≥ 1 | 96 (36) | 29 (33) | 32 (36) |
Severe | n = 333 | n = 155 | n = 154 |
0 | 185 (56) | 85 (55) | 83 (54) |
≥ 1 | 148 (44) | 70 (45) | 70 (46) |