Fig. 4

Association between age at onset and age at referral. A Age at referral for patients diagnosed with late-infantile, juvenile, and adult-onset disease. The adult-onset group comprised two cases of Kufs disease type A, and one case of teenage progressive myoclonic epilepsy. Each dot represents one of 88 patients for which age was provided. Grey areas show the smoothed distribution of ages or years, white boxes interquartile ranges, and lines inside them the medians. B Correlation between age of onset and age of referral in 32 patients for which both ages were recorded. Also shown are a least square regression line with a 95% confidence interval (grey area), and the Pearson correlation coefficient (R) with significance level. A linear model was fitted without considering the outlier in the upper right corner of the plot