Table 1. Clinical, therapeutic, pathological and prognostic characteristics of the 5 patients included in this study
No. | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 |
|---|---|---|---|---|---|
Gender/Age (year) | M/46 | M/36 | F/29 | M/55 | M/29 |
Onset symptoms | Dizziness,anorexia, polydipsia/polyuria, visual deterioration | Headache, poor energy, hypogonadism | Headache | Dizziness, poor energy, polydipsia/polyuria | Incidental |
Disease duration (m) | 24 | 12 | 1 | 3 | 1 |
Neurological findings (pre-op) | Visual acuity: L 0.12, R 0.4; bitemporal hemianopsia | NSPS | NSPS | cognitive/memory decline; weakness of lower limb | NSPS |
Treatment and Approach | Transsylvian | Transcallosal | Transsphenoidal | (1) V-P shunt (2)Transsylvian | Watchful waiting |
Extent of resection | STR | GTR | STR | GTR | Undone |
Pathology | ACP | ACP | CP | ACP | Undone |
GNAS mutation | Negative | Negative | Negative | Undone | Undone |
GNAS expression | Positive | Positive | Positive | Undone | Undone |
Endocrine deficits (pre-op) | Hypogonadism | Hypothyroidism; hyperprolactin | Hyperprolactin; hyperthyroidism | Hypothyroidism | Nomal |
Endocrine deficits (post-op) | Panhypopituitarism | Hypothyroidism | Transient hypothyroidism | Panhypopituitarism | Nomal |
Complications | Transient hypernatremia; central fever | Transient DI | Meningitis; visual loss | DI; thrombus of lower extremity veins | Undone |
Follow-up time (m) | 98 | 97 | 57 | 6 | 28 |
Outcome | Residual without progression; hormone replacement therapy | No recurrence | No recurrence | Died of pulmonary embolism | No progress |