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Table 3 Registrations of musculoskeletal surgery in Marfan syndrome

From: Musculoskeletal diseases in Marfan syndrome: a nationwide registry study

Surgery

NOMESCO

Number of MFS/controls

HR MFS versus controls (95% CI)

HR MFS only, women versus men * (95% CI)

Combined†

KN

94/5949

1.76 (1.43–2.16)

0.90 (0.60–1.35)

Non-spinal surgery

 

83/5786

1.57 (1.27–1.95)

0.85 (0.55–1.31)

Surgery of the spine

Spine and neck

KNA

17/248

7.5 (4.6–12.3)

2.06 (0.76–5.58)

Scoliosis

KNAG71-75

14/87

17.6 (10.0–31.1)

2.71 (0.85–8.67)

KNAT21-25

Surgery of the chest wall

Correction pectus carinatum

KGAF00

6/ < 4

 > 200

N/A

Correction pectus excavatum

KGAF03

7/9

77.5 (28.9–208.1)

N/A

Upper extremity surgery

Shoulder and upper arm

KNB

8/788

1.07 (0.53–2.15)

0.87 (0.21–3.60)

Elbow and forearm

KNC

14/862

1.68 (0.99–2.85)

0.28 (0.08–1.05)

Wrist and hand

KND

12/1314

0.95 (0.54–1.68)

1.01 (0.32–3.18)

Pelvic and lower extremity surgery

Pelvis

KNE

 < 4/63

N/A

N/A

Hip joint and thigh

KNF

17/617

2.95 (1.82–4.78)

1.11 (0.42–2.88)

Hip arthroplasty

KNFB

4/222

1.89 (0.70–5.10)

1.05 (0.15–7.51)

Knee and lower leg

KNG

25/2289

1.13 (0.76–1.68)

0.69 (0.31–1.54)

Ankle and foot

KNH

28/996

3.08 (2.12–4.49)

1.40 (0.66–2.96)

Resection of joint, arthroplasty and arthrodesis in ankle and foot

KNHG

14/88

16.9 (9.6–29.8)

0.97 (0.34–2.789)

Osteotomy of ankle or foot

KNHK50-69

7/151

4.80 (2.25–10.24)

1.48 (0.33–6.62)

Myotomy or tenotomy of ankle or foot

KNHL39

6/41

17.3 (7.3–41.4)

2.17 (0.39–12.0)

Correction of deformity of ankle or foot using external or internal fixation

KNHT49

 < 4/13

17.7 (3.9–79.7)

N/A

Removal of internal fixation device from ankle or foot

KNHU49

14/178

8.3 (4.8–14.4)

1.41 (0.49–4.08)

  1. Registrations of surgery according to the Nordic Classification of Surgical Procedures (NOMESCO) in patients diagnosed with Marfan syndrome and in their controls, combined and divided into eight main groups (in bold), and into subgroups. Further, data on the correction of pectus carinatum and pectus excavatum are given. One patient may have several registrations of surgery
  2. *Using year of birth as a co-variate. HR, Hazard ratio. N/A not available due to limited number of events †Each person could have a registration in more than one main group or subgroup