From: Musculoskeletal diseases in Marfan syndrome: a nationwide registry study
Surgery | NOMESCO | Number of MFS/controls | HR MFS versus controls (95% CI) | HR MFS only, women versus men * (95% CI) |
---|---|---|---|---|
Combined†| KN | 94/5949 | 1.76 (1.43–2.16) | 0.90 (0.60–1.35) |
Non-spinal surgery |  | 83/5786 | 1.57 (1.27–1.95) | 0.85 (0.55–1.31) |
Surgery of the spine | ||||
Spine and neck | KNA | 17/248 | 7.5 (4.6–12.3) | 2.06 (0.76–5.58) |
Scoliosis | KNAG71-75 | 14/87 | 17.6 (10.0–31.1) | 2.71 (0.85–8.67) |
KNAT21-25 | ||||
Surgery of the chest wall | ||||
Correction pectus carinatum | KGAF00 | 6/ < 4 |  > 200 | N/A |
Correction pectus excavatum | KGAF03 | 7/9 | 77.5 (28.9–208.1) | N/A |
Upper extremity surgery | ||||
Shoulder and upper arm | KNB | 8/788 | 1.07 (0.53–2.15) | 0.87 (0.21–3.60) |
Elbow and forearm | KNC | 14/862 | 1.68 (0.99–2.85) | 0.28 (0.08–1.05) |
Wrist and hand | KND | 12/1314 | 0.95 (0.54–1.68) | 1.01 (0.32–3.18) |
Pelvic and lower extremity surgery | ||||
Pelvis | KNE |  < 4/63 | N/A | N/A |
Hip joint and thigh | KNF | 17/617 | 2.95 (1.82–4.78) | 1.11 (0.42–2.88) |
Hip arthroplasty | KNFB | 4/222 | 1.89 (0.70–5.10) | 1.05 (0.15–7.51) |
Knee and lower leg | KNG | 25/2289 | 1.13 (0.76–1.68) | 0.69 (0.31–1.54) |
Ankle and foot | KNH | 28/996 | 3.08 (2.12–4.49) | 1.40 (0.66–2.96) |
Resection of joint, arthroplasty and arthrodesis in ankle and foot | KNHG | 14/88 | 16.9 (9.6–29.8) | 0.97 (0.34–2.789) |
Osteotomy of ankle or foot | KNHK50-69 | 7/151 | 4.80 (2.25–10.24) | 1.48 (0.33–6.62) |
Myotomy or tenotomy of ankle or foot | KNHL39 | 6/41 | 17.3 (7.3–41.4) | 2.17 (0.39–12.0) |
Correction of deformity of ankle or foot using external or internal fixation | KNHT49 |  < 4/13 | 17.7 (3.9–79.7) | N/A |
Removal of internal fixation device from ankle or foot | KNHU49 | 14/178 | 8.3 (4.8–14.4) | 1.41 (0.49–4.08) |