Transcriptomic analysis of patients with clinical suspicion of maturity-onset diabetes of the young (MODY) with a negative genetic diagnosis

Table 1 Clinical and biochemical characteristics of the patients

Case	Age (years)	Sex	Age at onset (years)	Family history of DM (n)	BMI (Kg/m²)	Biochemical parameters			Secondary complications	Antidiabetic therapy
Case	Age (years)	Sex	Age at onset (years)	Family history of DM (n)	BMI (Kg/m²)	HbA1c (%)	Fasting glucose (mg/dl)	C-peptide (ng/ml)	Secondary complications	Insulin	Metformin	DDP4i	SGLT2i	GLP-1 RAs
M1	61	M	48	7	31.8	7.2	110	1.1	No	Yes	No	No	Yes	No
M2	85	M	49	4	19.6	7	126	0.8	Yes	No	Yes	No	No	No
M3	47	M	27	5	25.1	6.9	128	0.5	Yes	Yes	Yes	No	Yes	No
M4	78	F	65	9	24.3	7.6	90	0.3	No	Yes	No	No	No	No
M5	34	F	25	2	20.8	7.5	122	1.8	No	No	No	Yes	No	No
M6	35	F	23	5	30.6	8.2	113	1.6	No	Yes	No	No	No	No
M7	53	M	18	2	25.6	8.2	142	1.3	Yes	Yes	Yes	Yes	No	No
M8	46	M	26	1	19.8	6	125	0.3	No	Yes	No	No	No	No
M9	35	M	14	–	27.5	8	191	0.7	No	Yes	No	No	No	No
M10	32	F	20	2	40.2	9.8	138	0.4	No	Yes	Yes	No	Yes	No
M11	55	M	27	6	27	6.9	145	–	No	No	Yes	No	No	No
M12	48	F	25	2	30.4	5.9	102	3	No	Yes	No	No	No	No
M13	48	M	46	3	24.8	6.8	159	0.8	No	No	Yes	No	No	No
M14	24	M	17	4	23.6	7.6	127	1.4	No	No	Yes	No	No	No
M15	42	F	11	3	38.7	6.2	90	0.57	Yes	No	No	No	No	Yes
M16	57	M	35	2	25.5	7.9	167	1.2	No	Yes	No	No	No	No
M17	38	F	35	–	29.1	7.3	124	0.5	No	Yes	No	No	No	No
M18	41	F	25	–	27.2	8.4	143	–	No	No	No	No	Yes	No
M19	38	M	35	2	22	6.4	124	1.4	No	No	No	No	No	No
C1	40	M	–	0	23.1	–	93	–	No	No	No	No	No	No
C2	35	F	–	0	20.1	–	92	–	No	No	No	No	No	No
C3	30	F	–	0	22.4	–	101	–	No	No	No	No	No	No
C4	58	M	–	1	19.4	–	96	–	No	No	No	No	No	No
C5	46	M	–	0	23.7	–	89	–	No	No	No	No	No	No
C6	39	M	–	1	24.6	–	88	–	No	No	No	No	No	No
C7	61	F	–	1	20.8	–	92	–	No	No	No	No	No	No
C8	47	M	–	0	22.9	–	90	–	No	No	No	No	No	No

BMI body mass index, DM diabetes mellitus, HbA1c glycosylated hemoglobin A1c, DDP4i dipeptidyl peptidase 4 inhibitors, M male, F female, n number, SGLT2i sodium glucose cotransporter 2 inhibitors, GLP-1 RAs glucagon-like peptide type 1 receptor agonist

ISSN: 1750-1172