Table 3 Diagnostic utility measures for different ALP thresholds during the two-year follow up evolution
ALP levels (IU/L) | S (%) | Sp (%) | PPV (%) | NPV (%) | +LR | −LR |
|---|---|---|---|---|---|---|
Baseline | ||||||
< 20 | 10.0 | 97.3 | 80.0 | 50.0 | 3.70 | 0.92 |
< 25 | 37.5 | 83.8 | 71.4 | 55.4 | 2.31 | 0.75 |
< 30 | 72.5 | 64.9 | 69.0 | 68.6 | 2.07 | 0.42 |
< 35 | 90.0 | 37.8 | 61.0 | 77.8 | 1.45 | 0.26 |
6-month visit | ||||||
< 20 | 18.2 | 96.4 | 85.7 | 50.0 | 5.06 | 0.85 |
< 25 | 48.5 | 85.7 | 80.0 | 58.5 | 3.39 | 0.60 |
< 30 | 78.8 | 50.0 | 65.0 | 66.7 | 1.58 | 0.42 |
< 35 | 87.9 | 35.7 | 61.7 | 71.4 | 1.37 | 0.34 |
One-year visit | ||||||
< 20 | 17.9 | 100 | 100 | 51.5 | ∞ | 0.82 |
< 25 | 48.7 | 91.2 | 86.4 | 60.8 | 5.53 | 0.56 |
< 30 | 76.9 | 61.8 | 69.8 | 70.0 | 2.01 | 0.37 |
< 35 | 89.7 | 26.5 | 58.3 | 69.2 | 1.22 | 0.39 |
18-month visit | ||||||
< 20 | 14.7 | 96.3 | 83.3 | 47.3 | 3.97 | 0.89 |
< 25 | 47.1 | 89.0 | 84.2 | 57.1 | 4.24 | 0.60 |
< 30 | 82.4 | 55.6 | 70.0 | 71.4 | 1.86 | 0.32 |
< 35 | 91.2 | 37.0 | 64.6 | 76.9 | 1.45 | 0.24 |
Two-year visit | ||||||
< 20 | 17.4 | 96.3 | 83.3 | 47.3 | 3.97 | 0.89 |
< 25 | 41.2 | 92.6 | 87.5 | 55.6 | 5.57 | 0.63 |
< 30 | 70.6 | 66.7 | 72.7 | 64.3 | 2.12 | 0.44 |
< 35 | 91.2 | 44.4 | 67.4 | 80.0 | 1.64 | 0.20 |