Fig. 1

Clinical features of the patient—Polymalformative syndrome including distichiasis (red arrow in a), palatine tooth (circled in red in b), uterine septum (red arrow in c), vesicoureteral reflux (d) and overweight (e). In part E we reported the increase in insulin requirement during childhood (arrow #1: 1.1 ui/kg) followed by the decrease in insulin requirement after the addition of metformin (arrow #2: 0.7 UI/kg). We show the addition effects of DPP4 inhibitors (arrow #3), and GLP1-RA (arrow #4). The dark area shows the values corresponding to overweight, while the area with points shows the values corresponding to obesity