Healthcare resource utilization, total costs, and comorbidities among patients with myotonic dystrophy using U.S. insurance claims data from 2012 to 2019

Table 2 Most impactful comorbidities among patients with DM compared with matched controls for the 12-month follow-up period^a^,b

ICD-9 or ICD-10 code	Description	DM cohort (N = 8,390)		Fold change^c
ICD-9 or ICD-10 code	Description	n	%	Fold change^c
787	GI system symptoms	1210	14.4	2.2
427	Cardiac dysrhythmias	1054	12.6	3.6
327	Organic sleep disorders	979	11.7	3.9
728	Disorders of muscle/ligament/fascia	957	11.4	3.2
G47	Sleep disorders	934	11.1	2.8
518	Other lung diseases	910	10.8	5.2
R06	Abnormalities of breathing	796	9.5	2.2
M62	Other disorders of muscle	773	9.2	3.4
781	Nervous/musculoskeletal system symptoms	685	8.2	3.9
788	Urinary system symptoms	675	8.0	2.1
794	Abnormal function study	610	7.3	3.6
799	Other ill-defined morbidity/mortality	579	6.9	4.9
785	Cardiovascular system symptoms	568	6.8	2.2
V45^d	Other postprocedural states	550	6.6	2.2
R53	Malaise and fatigue	686	8.2	2.0

^aExcludes ICD9 359 (muscular dystrophies) and ICD10 G71 (primary disorders of muscle) as these are the ICD codes for inclusion in the study
^bAffects more than 5% of the DM Cohort and at least 2X more than the controls with P value < 0.0001 during the 12-month follow-up period
^cFold change is the multiple of how many more times the disease cohort is affected by the specific comorbidity compared to controls
^dV45 is the ICD-9 alphanumeric code for “Other postprocedural states”; the same code is also used in ICD-10 to indicate “Car occupant injured in collision with railway train or railway vehicle.” The V45 shown here is an ICD-9 code

ISSN: 1750-1172