Healthcare resource utilization, total costs, and comorbidities among patients with myotonic dystrophy using U.S. insurance claims data from 2012 to 2019

Table 1 Baseline demographic characteristics of patients with DM or cDM compared to pre-matched controls^a

	DM cohort (N = 8541)	Non-DM pre-matched control cohort (N = 5,595,054)	P value	cDM cohort (N = 242)	Non-cDM pre-matched control cohort (N = 344,217)	P value
Age, years						0.1334
Mean ± SD	46.0 ± 18.9	48.2 ± 22.9	< .0001	0.5 ± 0.5	0.5 ± 0.5
Median	48.0	51.0	< .0001	0	1.0
Age group, n (%)						0.1228
0–11 months				129 (53.3)	166,685 (48.4)
12–23 months				113 (46.7)	177,532 (51.6)
2–9 years	353 (4.1)	363,243 (6.5)
10–17 years	479 (5.6)	353,848 (6.3)
18–39 years	2003 (23.5)	1,234,691 (22.1)
≥ 40 years	5706 (66.8)	3,643,272 (65.1)	< .0001
40–64 years	4328 (50.7)	2,079,171 (37.2)
≥ 65 years	1378 (16.1)	1,564,101 (28.0)	< .0001
Gender, n (%)						0.2039
Female	4712 (55.2)	3,336,346 (59.6)	< .0001	105 (43.4)	163,394 (47.5)
Male	3829 (44.8)	2,258,708 (40.4)		137 (56.6)	180,823 (52.5)
Payer type^b, n (%)			< .0001			< .0001
Cash	3 (0)	1,214 (0)		0	66 (0)
Medicaid	585 (6.8)	144,011 (2.6)		54 (22.3)	30,681 (8.9)
Medicare/medicare part D	2,358 (27.6)	1,269,856 (22.7)		3 (1.2)	5,874 (1.7)
Third party	5,595 (65.5)	4,179,973 (74.7)		185 (76.4)	307,596 (89.4)
Other/unknown	0	0		0	0

DM, myotonic dystrophy; cDM, congenital DM; SD, standard deviation
^aAssessed on index date if available as first option, or over the pre-index period
^bPrioritized payer type from a medical claim (Dx) in the pre-index (closest to index date) period or, if none, used payer type from a pharmacy claim (Rx) (closest to index date)
^cP values were obtained using the chi-square test for categorical variables and the Wilcoxon rank-sum test for continuous variables; SMD were used for comparisons between DM cohort vs non-DM control cohort and between cDM cohort vs non-cDM control cohort

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