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Table 2 Results of Cochet-Bonnet esthesiometry and in vivo confocal microscopy (IVCM) parameters

From: Eight months follow-up of corneal nerves and sensitivity after treatment with cenegermin for neurotrophic keratopathy

 

0 wk

8 wk

P (0–8 wk)

2 mth (fu)

p (8 wk–2 mth)

4 mth (fu)

p (2–4 mth)

8 mth (fu)

p (4–8 mth)

Median (IQR)

Median (IQR)

Median (IQR)

Median (IQR)

Median (IQR)

CBE

         

 C

0 (0)

2.5 (8.75)

0.01

12.5 (18.75)

 < 0.01

17.5 (26.25)

 < 0.01

25 (32.5)

0.05

 I

0 (3,75)

5 (8.75)

 < 0.01

15 (18.75)

 < 0.01

22.5 (13.75)

 < 0.01

30 (20)

0.08

 N

0 (5)

10 (10)

 < 0.01

20 (13.75)

 < 0.01

30 (17.5)

 < 0.01

35 (36.25)

0.07

 S

2.5 (5)

12.5 (15)

 < 0.01

22.5 (26.25)

 < 0.01

37.5 (23.75)

 < 0.01

37.5 (22.5)

0.07

 T

5(5)

15 (18.75)

 < 0.01

25 (23.75)

 < 0.01

37.5 (25)

 < 0.01

40 (23.75)

0.15

CNFL

         

 C

0 (0)

0 (2.30)

0.04

0 (4.03)

0.04

1.51 (8.1)

0.01

0 (9.42)

0.52

 I

0 (1.48)

0 (4.02)

0.02

0 (6.26)

0.02

4.53 (9.46)

 < 0.01

8.37 (8.96)

 < 0.01

 N

0 (1.99)

0 (3.89)

0.02

5.06 (6.41)

 < 0.01

8.13 (6.11)

 < 0.01

11.01 (13.25)

0.11

 S

0 (2.82)

3.66 (6.63)

 < 0.01

6.74 (7.8)

 < 0.01

12.28 (10.46)

 < 0.01

13.64 (12.45)

0.06

 T

1.99 (3.74)

4.63 (7.26)

0.01

6.55 (7.03)

 < 0.01

11.16 (10.51)

 < 0.01

12.06 (13)

0.08

CTBD

         

 C

0 (0)

0 (0)

0.32

0 (4.69)

0.13

0 (6.25)

0.05

0 (6.25)

0.78

 I

0 (0)

0 (0)

0.06

0 (4.69)

0.06

0 (12.5)

0.04

9.38 (10.94)

0.01

 N

0 (0)

0 (0)

0.06

3.13 (6.25)

0.01

6.25 (6.25)

0.01

12.5 (10.94)

0.32

 S

0 (5.31)

0 (6.25)

0.05

6.25 (12.5)

0.02

12.5 (6.25)

 < 0.01

12.5 (12.5)

0.26

 T

0 (1.88)

0 (6.25)

0.01

6.25 (12.5)

0.02

12.5 (6.25)

 < 0.01

12.5 (15.63)

0.67

CNFraD

         

 C

0 (0)

0 (0)

0.32

0 (0.87)

0.08

0.58 (1.21)

0.01

0 (1.39)

0.64

 I

0 (0)

0 (1.16)

0.02

0 (1.2)

0.03

1.18 (0.28)

 < 0.01

1.28 (0.27)

0.01

 N

0 (0)

0 (1.17)

0.02

1.18 (0.94)

 < 0.01

1.25 (0.24)

 < 0.01

1.31 (1.17)

0.22

 S

0 (1.07)

1.15 (1.23)

 < 0.01

1.19 (0.15)

 < 0.01

1.36 (0.26)

 < 0.01

1.36 (0.22)

0.06

 T

0 (1.04)

1.16 (1.26)

0.01

1.2 (0.19)

 < 0.01

1.36 (0.24)

 < 0.01

1.32 (0.28)

0.27

  1. There was an overall increasing trend for all values and a statistically significant difference between contiguous time intervals (p). Even when the median values were 0, an increase in IQR denoted an increase in the parameters’ values in some patients. 0 wk denotes 0 week (baseline, start of treatment); 8 wk 8 weeks (end of treatment); 2 mth (fu) 2-month follow-up; 4 mth (fu) 4-month follow-up; 8 mth (fu) 8-month follow-up
  2. C, central; CBE, Cochet-Bonnet esthesiometry; CNFL, corneal nerve fiber length; CNFraD, corneal nerve fiber fractal
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172