Table 2 Characteristics of the couples involved in PGT-M
Patient ID | Patient gender | Female age | Female karyotype | Male age | Male karyotype | Mutation assessed | Reference source | ACMG | ClinVar | Cycle | No. of retrieved oocytes | No. of MII oocytes | No. of biopsied blastocysts |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case1 | Male | 27 | 46,XX | 30 | 46,XY | STK11c.911G>C (p.Arg304Pro) | Husband's father | P | P | 1 | 13 | 12 | 5 |
Case2 | Male | 36 | 46,XX | 36 | 46,XY | STK11c.527A>G (p.D176G) | Couple's daughter | LP | LP | 1 | 6 | 6 | 4 |
Case3 | Female | 28 | 46,XX | 28 | 46,XY | STK11c.580G>A (P.Asp194.Asn) | Husband's father | P | P/LP | 1 | 24 | 20 | 13 |
Case4 | Female | 30 | 46,XX | 28 | 46,XY | STK11EX1DEL and EX8-9DEL | Wife's brother | P | – | 1 | 22 | 21 | 3 |
Case4 | Female | 30 | 46,XX | 28 | 46,XY | STK11EX1DEL and EX8-9DEL | Wife's brother | P | – | 2 | 23 | 22 | 7 |