Organ system | Clinical manifestations (signs/symptoms) | |
---|---|---|
Pediatric | Adult | |
Peripheral neuropathy | Neuropathic pain (Fabry crises) | Present or past experience of neuropathic pain |
Hypohidrosis, heat intolerance | Hypohidrosis, heat intolerance | |
Hearing loss, vertigo | Hearing loss, vertigo | |
Nausea, vomiting, diarrhea | Nausea, vomiting, diarrhea | |
Abdominal pain | Abdominal pain | |
Postprandial bloating and pain, early satiety | Postprandial bloating and pain, early satiety | |
Difficulty gaining weight | Difficulty gaining weight | |
Cerebrovascular involvement | Cerebral microvascular ischemic involvement | Significant white matter lesions |
Transient ischemic attacks | ||
Ischemic strokes | ||
Neuropsychiatric phenotype | ||
Renal | Microalbuminuria, proteinuria | Albuminuria overt proteinuria |
Progressive chronic kidney disease | ||
Kidney failure | ||
End-stage renal disease necessitating renal replacement treatments | ||
Cardiac | Impaired heart rate variability | Left ventricular hypertrophy |
Arrhythmias | Hypertrophic cardiomyopathy | |
ECG abnormalities (shortened PR interval) | Cardiac arrhythmias | |
Mild valvular insufficiency | Valvular disease | |
Aortic dilatation at Valsalva sinuses | ||
Dermatological | Angiokeratomas | Angiokeratomas |
Sweating abnormalities (hypohidrosis) | Linear telangiectasia | |
Lymphedema | ||
Hypotrichosis | ||
Ocular | Corneal deposits (cornea verticillata) and lenticular opacities | Corneal deposits (cornea verticillata) and lenticular opacities |
Vasculopathy (conjunctiva, retina) | Vasculopathy (conjunctiva, retina) |