Table 2 Summary of the causal effects of ALS on blood pressure via MR methods

N SNPs

5

5

Cochran’s Q

 Q

7.525

7.002

 p value

0.111

0.136

Simple median

 OR (95% CI)

1.069 (0.877, 1.302)

1.22 (0.863, 1.726)

 P value

0.511

0.260

Weighted median

 OR (95% CI)

1.094 (0.922, 1.297)

1.265 (0.934, 1.713)

 P value

0.304

0.129

MR Egger

 OR (95% CI)

1.349 (0.863, 2.108)

1.686 (0.755, 3.765)

 P value

0.280

0.292

Inverse variance weighted-mre

 OR (95% CI)

1.024 (0.841, 1.246)

1.126 (0.809, 1.566)

 P value

0.815

0.482

MR Egger

 Intercept

− 0.045

− 0.066

 P value

0.278

0.360

MR-PRESSO

 Outlier-corrected

NA

NA

 Global test P value

0.203

0.223

 Distortion test

NA

NA