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Table 1 Summary of the causal effects of each trait on ALS via different MR methods

From: Assessing the role of blood pressure in amyotrophic lateral sclerosis: a Mendelian randomization study

 

DBP

SBP

CCB

N SNPs

397

400

47

F statistics

31,000

29,400

3180

Cochran’s Q

 Q

446.290

431.440

40.603

 p value

0.041

0.127

0.697

Simple median

 OR (95% CI)

0.990 (0.977, 1.004)

1.006 (0.993, 1.018)

0.987 (0.964, 1.010)

 P value

0.178

0.624

0.254

Weighted median

 OR (95% CI)

0.991 (0.977, 1.006)

1.006 (0.994, 1.019)

0.987 (0.964, 1.011)

 P value

0.248

0.590

0.277

MR Egger

 OR (95% CI)

0.983 (0.961, 1.007)

1.007 (0.985, 1.029)

1.017 (0.970, 1.067)

 P value

0.165

0.163

0.486

Inverse variance weighted-mre

 OR (95% CI)

0.991 (0.982, 1.001)

1.006 (0.998, 1.015)

0.985 (0.971, 1.000)

 P value

0.074

0.397

0.049

MR Egger

 Intercept

0.002

− 0.003

− 0.010

 P value

0.461

0.246

0.171

MR-PRESSO

 Outlier-corrected

NA

NA

NA

 Global test P value

0.042

0.140

0.720

 Distortion test

NA

NA

NA

Multivariable MR

 OR (95% CI)

0.978 (0.960, 0.996)

1.014 (1.003, 1.025)

NA

 P value

0.017

0.015

NA

  1. DBP diastolic blood pressure, SBP systolic blood pressure, ALS amyotrophic lateral sclerosis, CCB calcium channel blocker, OR odds ratio, CI confidence interval, MR Mendelian randomization, SNP single-nucleotide polymorphism