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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Assessing the role of blood pressure in amyotrophic lateral sclerosis: a Mendelian randomization study

Fig. 1

Flow chart showing the process for the Mendelian randomization analyses. The number in the line indicates 3 key assumptions for MR. Assumption 1: The selected genetic variances are not related to other confounders. Assumption 2: The selected genetic variances are significantly related to the exposure. Assumption 3: The selected genetic variances are significantly related to the risk of the outcome only through the pathway from exposure. GWAS, genome-wide association studies; MR, Mendelian randomization; SNP, single-nucleotide polymorphism; DBP, diastolic blood pressure; SBP, systolic blood pressure

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172