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Table 3 Diagnostic codes for long-term sick leave

From: Porphyria cutanea tarda and patterns of long-term sick leave and disability pension: a 24-year nationwide matched-cohort study

Diagnosis (ICPC-2)

Cases (one count per person per diagnosis)

Crude prevalence per 100

Incidence rate ratios (95% CI)

General and unspecific (ICPC2: A)

Reference (total)

19,215/21,360

10.0

1.0

PCT (total)

68/534

12.7

1.1 (0.9, 1.4)

 Reference

877/9120

9.6

1.0

 Sporadic PCT

34/228

14.9

1.4 (1.0, 2.0)

 Reference

1065/9600

11.1

1.0

 Familial PCT

31/240

12.9

1.0 (0.7, 1.5)

Weakness (ICPC2: A04)

Reference (total)

809/21,360

3.8

1.0

PCT (total)

29/534

5.4

1.2 (0.8, 1.8)

 Reference

305/9120

3.3

1.0

 Sporadic PCT

11/217

4.8

1.2 (0.7, 2.2)

 Reference

423/9600

4.4

1.0

 Familial PCT

17/240

7.1

1.4 (0.9, 2.3)

Digestive (ICPC2: D)

Reference (total)

280/21,360

1.3

1.0

PCT (total)

15/534

2.8

1.9 (1.1, 3.1)

 Reference

120/9120

1.3

1.0

 Sporadic PCT

9/217

4.0

2.5 (1.3, 4.8)

 Reference

130/ 9600

1.4

1.0

 Familial PCT

5/240

2.1

1.4 (0.6, 3.4)

Hypertension/ elevated blood pressure (ICPC2: K85-K87)

Reference (total)

657/21,360

3.1

1.0

PCT (total)

14/534

2.6

0.8 (0.5, 1.3)

 Reference

291/9120

3.2

1.0

 Sporadic PCT

8/217

3.5

1.1 (0.5, 2.1)

 Reference

289/9600

3.0

1.0

 Familial PCT

3/240

1.3

0.2 (0.1, 1.2)

Ischemic heart disease (ICPC2: K74)

Reference (total)

297/21,360

1.4

1.0

PCT (total)

3/534

0.6

0.4 (0.1, 1.4)

 Reference

142/9120

1.6

1.0

 Sporadic PCT

0/217

0.0

0.0 (0.0, 0.0)

 Reference

113/9600

1.2

1.0

 Familial PCT

1/240

0.4

0.4 (0.1, 2.6)

Muscle sympt/pain, joint sympt/pain (ICPC2: L18,-L20)

Reference (total)

801/21,360

3.8

1.0

PCT (total)

31/534

5.8

1.4 (1.0, 2.1)

 Reference

345/9120

3.8

1.0

 Sporadic PCT

19/217

8.3

2.1 (1.3, 3.3)

 Reference

376/9600

3.9

1.0

 Familial PCT

11/240

4.6

1.1 (0.6, 2.0)

Acute stress reaction (anxiety) (ICPC2: P02)

Reference (total)

1209/21,360

5.7

1.0

PCT (total)

33/534

6.2

0.9 (0.6, 1.2)

 Reference

464/9120

5.1

1.0

 Sporadic PCT

16/217

7.0

1.1 (0.7, 1.8)

 Reference

642/9600

6.7

1.0

 Familial PCT

14/240

5.8

0.7 (0.4, 1.2)

Feeling depressed/depressive disorders (ICPC2: P03)

Reference (total)

2612/21,360

12.2

1.0

PCT (total)

73/534

13.7

1.0 (0.8, 1.3)

 Reference

1074/9120

11.8

1.0

 Sporadic PCT

35/217

15.4

1.2 (0.8, 1.7)

 Reference

1277/9600

13.3

1.0

 Familial PCT

34/240

14.2

1.0 (0.7, 1.4)

Endocrine, metabolism, disorders (ICPC2:T99)

Reference (total)

87/21,360

0.4

1.0

PCT (total)

48/534

9.0

13.1 (10.2, 16.8)

 Reference

25/9120

0.3

1.0

 Sporadic PCT

18/217

7.9

15.0 (10.1, 22.3)

 Reference

52/9600

0.5

1.0

 Familial PCT

11/240

10.8

13.3 (9.5, 18.7)

Urological disorder/symptoms (ICPC2: U14)

Reference (total)

386/21,360

1.8

1.0

PCT (total)

11/534

2.1

1.0 (0.6, 1.9)

 Reference

173/9120

1.9

1.0

 Sporadic PCT

6/217

2.6

1.3 (0.6, 2.8)

 Reference

171/9600

1.8

1.0

 Familial PCT

4/240

1.7

0.9 (0.3, 2.3)

  1. Incident rate ratios calculated by Poisson regression with robust standard errors and offset for the natural log of months on study. Persons with unclassified PCT were removed due to small numbers. ICPC-2 = International Classification of Primary Care, 2nd edition. ICPC-2 codes reflect the diagnostic reason for long-term sick leave. Other diagnoses that were investigated, but had counts less than 5 included acute myocardial disease, n = 3 (ICPC2: K75); peripheral neuritis/ neuropathy, n = 1 (ICPC2: N94), feeling anxious/nervous/tense, n = 3 (ICPC2: P01); affective disorder, n = 4 (ICPC2: P73) anxiety disorder, n = 3 (ICPC2: P74), suicide attempt, n = 0 (ICPC2:P77), kidney symptom/ complaint, n = 0 (ICPC2: U14)
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172