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Table 1 Fetal Hb Bart’s identified in each corresponding α-globin genotype

From: Diagnostic value of fetal hemoglobin Bart’s for evaluation of fetal α-thalassemia syndromes: application to prenatal characterization of fetal anemia caused by undiagnosed α-hemoglobinopathy

Item

Type

Number

α-Genotype

Hb Bart’s (%)

1

Non α-thalassemia

152

αα/αα

0

2

Hb Bart’s Hydrops fetalis

57

--/--

81.5 ± 3.6 (74.7–89.9)

3

α0-thalassemia trait

44

--/αα

4.8 ± 1.2 (1.9–8.0)

4

α+-thalassemia trait

26

-α/αα

0.7 ± 0.4 (0–1.5)

5

Homozygous Hb CS and Hb CS/Hb PS

14

αCSα/αCSα (11), αCSα/αPSα (3)

11.2 ± 2.6 (7.4–16.7)

6

Hb CS trait

12

αCSα/αα

1.3 ± 0.8 (0.4–2.9)

7

Hb H disease

7

--/-α

19.2 ± 1.5 (16.9–22.1)

8

Hb H-CS and Hb H-Pakse’ diseases

6

--/αCSα (5), --/αPSα (1)

26.3 ± 1.8 (23.4–28.2)

9

α+-thalassemia/Hb CS

5

αCSα/- α

7.3 ± 2.2 (4.8–9.9)

10

Homozygous α+-thalassemia

4

-α/-α

4.1 ± 1.5 (2.1–5.8)

11

Rare α+-thalassemia trait

2

ααQP/αα

0.5

   

ααAms/αα

0.5

12

Hb H-QZ disease

1

--/αQZα

33.7

13

Unknown

2

na

0.7, 1.4

 

Total

332

  
  1. Values are presented as mean ± SD (range)
  2. na not available
  3. CS = Hb Constant Spring, PS = Hb Pakse’, QP = Hb Queens Park, Ams = Hb Amsterdam A1, QZ = Hb Quong Sze