Skip to main content

Table 1 Patient descriptions

From: Intermediate-dose cytarabine is an effective therapy for adults with non-Langerhans cell histiocytosis

Patient #

Diagnosis

Age at cytarabine initiation (years)

Gender

Sites of disease

Gene mutations

Previous therapies

Total number of cytarabine cycles

Response

Progression or disease recurrence? (time from start of therapy to relapse)

Follow-up duration (months)

Maintenance or recurrent treatment

1

ECD

45

F

CNS, bones, pituitary

None-detected

None

4

PR

No

48

Interferon-α

2

ECD

24

F

CNS, bones, obit, lung, retroperitoneum

BRAF V600E

None

4

PR

No

39

Interferon-α

3

ECD

56

M

bones, vasculature, orbit, lung, nasal sinus, retroperitoneum

BRAF V600E

Interferon-α

6

PR

No

13

Interferon-α

4

ECD

36

F

bones, vasculature, orbit, thyroid, pericardium, retroperitoneum

None-detected

Interferon-α

4

PD

Yes (5 months)

12

Sirolimus/prednisone

5

ECD

50

M

CNS, bones, pituitary, thyroid, vasculature, nerve root

NA

None

6

PR

No

17

Interferon-α

6

ECD

51

F

CNS, bones

BRAF V600E

None

6

PR

Yes (19 months)

25

Interferon-α → vemurafenib

7

ECD

53

F

Bones, heart, pericardium

BRAF V600E

Interferon-α

2

PD (died)

Yes (6 months)

6

NA

8

ECD

51

F

CNS, bones, skin, thyroid, retroperitoneum, pancreas

None-detected

None

4

PR

No

9

Interferon-α

9

ECD

52

M

CNS, Bone, pericardium, orbit, retroperitoneum, vasculature, lung

None-detected

Interferon-α

5

PR

No

68

Interferon-α

10

ICH

22

M

Bones, CNS (Spinal cord)

NA

None

6

PR

No

14

NA

11

RDD

34

M

CNS

None-detected

None

6

PR

No

23

Lenalidomide/dexamethasone

12

RDD

37

M

CNS, dura

NA

Surgery

6

CR

No

12

NA

13

RDD

70

M

Bones, orbit, nasal sinus, glottis

BRAF R188G MAP2K1D147G1

Methylprednisolone

4

PR

No

8

Lenalidomide/dexamethasone

14

RDD

18

M

CNS, pituitary

BRAF V600E wild type

None

6

PR

No

61

Interferon-α

15

RDD

50

M

CNS, dura

NA

Methylprednisolone/Rituximab

6

PR

No

60

Interferon-α

16

Unclassified histiocytosis

22

M

Bones, skin, gingiva

NA

COP, CHOP, lenalidomide

3

PR

No

6

NA

  1. COP: Cyclophosphamide/vincristine/prednisone; CHOP: Cyclophosphamide/epirubicin/vincristine/predisone